David Geffen School of Medicine, University of California at Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA.
Cancer Prev Res (Phila). 2010 Apr;3(4):420-3. doi: 10.1158/1940-6207.CAPR-10-0052. Epub 2010 Mar 23.
This perspective on Varella-Garcia et al. (beginning on p. 447 in this issue of the journal) discusses the role of sputum-based biomarkers in the risk assessment and early detection of lung cancer. The importance of the detection of sputum epithelial chromosomal aneusomy by fluorescence in situ hybridization (FISH) as a potential risk or early-detection biomarker is discussed in the context of other biomarkers and models in lung carcinogenesis. The presently reported findings on FISH in sputum cells are an important contribution worthy of further investigation in defined clinical settings.
这篇观点文章由 Varella-Garcia 等人撰写（本期杂志第 447 页开始），讨论了基于痰液的生物标志物在肺癌风险评估和早期检测中的作用。文章还讨论了通过荧光原位杂交（FISH）检测痰液上皮细胞染色体非整倍体作为潜在风险或早期检测生物标志物的重要性，并将其置于肺癌发生的其他生物标志物和模型的背景下进行了讨论。目前关于 FISH 在痰液细胞中的研究结果是一项重要的贡献，值得在明确的临床环境中进一步研究。
