Coordinating Center for Clinical Trials, National Cancer Institute, 6120 Executive Boulevard, Bethesda, MD 20852-4910, USA.
Cancer Prev Res (Phila). 2010 Apr;3(4):416-9. doi: 10.1158/1940-6207.CAPR-10-0045. Epub 2010 Mar 23.
This perspective on Varella-Garcia et al. (beginning on p. 447 in this issue of the journal) examines the role of interphase fluorescence in situ hybridization for the early detection of lung cancer. This work is an important step toward identifying and validating a molecular marker in sputum samples for lung cancer early detection and highlights the value of establishing cohort studies with biorepositories of samples collected from participants followed over time for disease development.
这篇关于 Varella-Garcia 等人的观点(本期杂志第 447 页开始)探讨了间期荧光原位杂交在肺癌早期检测中的作用。这项工作是朝着在痰液样本中识别和验证肺癌早期检测的分子标志物迈出的重要一步,并强调了通过建立队列研究和生物样本库来收集随时间随访疾病发展的参与者的样本的价值。