Department of Pharmacy Practice, Wayne State University, Detroit, Michigan, USA.
Diabetes Care. 2010 Jun;33(6):1373-5. doi: 10.2337/dc09-2199. Epub 2010 Mar 23.
To describe 25-hydroxy vitamin D (25-OH-D) levels and examine associations between 25-OH-D levels and insulin resistance (IR), metabolic syndrome (MS), and glucose intolerance in Arab Americans.
Serum 25-OH-D levels were measured in a representative, cross-sectional sample of 542 Arab Americans with IR (46%), MS (33%), and glucose intolerance (42%).
Vitamin D insufficiency (5 to <20 ng/ml) was present in 75% and hypovitaminosis D (20 to <40 ng/ml) in 24% of participants. In men, 25-OH-D levels were lower in those with glucose intolerance than normoglycemia (P = 0.01). No such difference was found in women. In men, 25-OH-D was negatively correlated with homeostasis model assessment of insulin resistance (r = -0.19; P = 0.0043), triglycerides (r = -0.18; P = 0.0069), fasting plasma glucose (r = -0.15; P = 0.027), and A1C (r = -0.14; P = 0.038). In women, 25-OH-D was positively correlated with HDL (r = 0.19; P = 0.0008).
Vitamin D insufficiency and hypovitaminosis D are extremely common among Arab Americans, and they are associated with IR, components of the MS, and glucose intolerance in men.
描述阿拉伯裔美国人的 25-羟维生素 D（25-OH-D）水平，并研究 25-OH-D 水平与胰岛素抵抗（IR）、代谢综合征（MS）和葡萄糖耐量异常之间的关系。
对具有 IR（46%）、MS（33%）和葡萄糖耐量异常（42%）的 542 名阿拉伯裔美国人的代表性横断面样本进行血清 25-OH-D 水平测量。
维生素 D 不足（5 至 <20ng/ml）占 75%，维生素 D 缺乏（20 至 <40ng/ml）占 24%。在男性中，葡萄糖耐量异常者的 25-OH-D 水平低于血糖正常者（P=0.01）。在女性中未发现这种差异。在男性中，25-OH-D 与稳态模型评估的胰岛素抵抗（r=-0.19；P=0.0043）、甘油三酯（r=-0.18；P=0.0069）、空腹血糖（r=-0.15；P=0.027）和 A1C（r=-0.14；P=0.038）呈负相关。在女性中，25-OH-D 与高密度脂蛋白（HDL）呈正相关（r=0.19；P=0.0008）。
维生素 D 不足和维生素 D 缺乏在阿拉伯裔美国人中极为常见，且与男性的 IR、MS 成分和葡萄糖耐量异常相关。
