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Genetic influence of vitamin D receptor gene polymorphisms on osteoporosis risk.维生素D受体基因多态性对骨质疏松症风险的遗传影响。
Int J Health Sci (Qassim). 2020 Jul-Aug;14(4):22-28.
2
Vitamin D deficiency in western dwelling South Asian populations: an unrecognised epidemic.西方居住的南亚人群中的维生素D缺乏：一种未被认识的流行病。
Proc Nutr Soc. 2020 Aug;79(3):259-271. doi: 10.1017/S0029665120000063. Epub 2020 Feb 12.
3
Current vitamin D status in European and Middle East countries and strategies to prevent vitamin D deficiency: a position statement of the European Calcified Tissue Society.目前欧洲和中东国家的维生素 D 状况以及预防维生素 D 缺乏的策略：欧洲钙化组织学会的立场声明。
Eur J Endocrinol. 2019 Apr;180(4):P23-P54. doi: 10.1530/EJE-18-0736.
4
The Relationship between 25 (OH) D Levels (Vitamin D) and Bone Mineral Density (BMD) in a Saudi Population in a Community-Based Setting.沙特社区人群中25（OH）D水平（维生素D）与骨密度（BMD）的关系。
PLoS One. 2017 Jan 3;12(1):e0169122. doi: 10.1371/journal.pone.0169122. eCollection 2017.
5
Low bone mineral density among young healthy adult Saudi women. Prevalence and associated factors in the age group of 20 to 36 years.沙特年轻健康成年女性的低骨矿物质密度。20至36岁年龄组的患病率及相关因素。
Saudi Med J. 2016 Nov;37(11):1225-1233. doi: 10.15537/smj.2016.11.16248.
6
Ethnic differences in bone geometry between White, Black and South Asian men in the UK.英国白人、黑人和南亚男性之间骨骼几何结构的种族差异。
Bone. 2016 Oct;91:180-5. doi: 10.1016/j.bone.2016.07.018. Epub 2016 Jul 22.
7
The relationship between serum 25(OH)D and bone density and microarchitecture as measured by HR-pQCT.血清25(OH)D与通过高分辨率外周定量计算机断层扫描（HR-pQCT）测量的骨密度和微结构之间的关系。
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8
Increasing trends and significance of hypovitaminosis D: a population-based study in the Kingdom of Saudi Arabia.维生素D缺乏症的上升趋势及其重要性：沙特阿拉伯王国的一项基于人群的研究。
Arch Osteoporos. 2014;9:190. doi: 10.1007/s11657-014-0190-3. Epub 2014 Sep 12.
9
The association between body composition, 25(OH)D, and PTH and bone mineral density in black African and Asian Indian population groups.非洲黑人与亚洲印度人群体中身体成分、25(OH)D、甲状旁腺激素（PTH）与骨密度之间的关联。
J Clin Endocrinol Metab. 2014 Jun;99(6):2146-54. doi: 10.1210/jc.2013-3968. Epub 2014 Mar 11.
10
Vitamin D deficiency amongst minority ethnic groups in the UK: a cross sectional study.英国少数民族群体的维生素 D 缺乏：一项横断面研究。
Int J Cardiol. 2013 Sep 1;167(5):2172-6. doi: 10.1016/j.ijcard.2012.05.081. Epub 2012 Nov 7.

英国阿拉伯、白种和南亚裔女性的骨密度及血清25-羟维生素D水平

Volumetric bone mineral density and serum 25-hydroxyvitamin D status in the UK dwelling Arab, Caucasian, and South Asian women.

作者信息

Hussein Khulood, Almaghrabi Safa

机构信息

Department of Physiology, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.

出版信息

Int J Health Sci (Qassim). 2023 Jan-Feb;17(1):44-52.

PMID:36704491
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9832911/
Abstract

OBJECTIVES

Little is known about ethnic differences in bone geometry, nor their association with 25-hydroxyvitamin D (25(OH)D), especially among ethnicities living in the same country. The purpose of this preliminary study was to investigate differences in bone geometry at the radius and tibia, as well as in 25(OH)D status, between Arab (A), South Asian (SA), and Caucasian (C) premenopausal women residing in the UK. The potential association between 25(OH)D concentration and indices of bone geometry was also assessed.

METHODS

Fifty-seven healthy premenopausal women (17 A, 18 SA, and 22 C), ranging in age from 18 to 51 years, underwent assessment of their volumetric bone mineral density and 25(OH)D concentration. Ethnic differences were assessed using ANOVA. Spearman's rho was used to analyze associations between 25(OH)D and pQCT bone variables.

RESULTS

At the 4% radius, Arab women had a lower BMC, as well as a smaller total bone area and trabecular area than did Caucasian women. At the 4% tibia, Arab women had a lower total vBMD than did South Asian women. Serum 25(OH)D among Arab (36.5(22.4SD)) and South Asian (31.4 (16.8SD)) women was significantly lower than in Caucasian women (81.9(20.0SD)) (P < 0.05). There were no statistically significant correlations between 25(OH)D and pQCT bone variables in any ethnic group.

CONCLUSIONS

This study suggests a possible need for attention to bone health in premenopausal Arab women as well as improvement in Vitamin D status in Arab and South Asian populations.

摘要

目的

目前对于骨骼几何结构的种族差异及其与25-羟基维生素D（25(OH)D）的关联了解甚少，尤其是在生活在同一个国家的不同种族之间。这项初步研究的目的是调查居住在英国的阿拉伯（A）、南亚（SA）和白种（C）绝经前女性在桡骨和胫骨的骨骼几何结构差异，以及25(OH)D水平差异。同时还评估了25(OH)D浓度与骨骼几何结构指标之间的潜在关联。

方法

57名年龄在18至51岁之间的健康绝经前女性（17名阿拉伯女性、18名南亚女性和22名白种女性）接受了骨体积密度和25(OH)D浓度评估。使用方差分析评估种族差异。采用Spearman秩相关系数分析25(OH)D与外周定量计算机断层扫描（pQCT）骨变量之间的关联。

结果

在桡骨4%处，阿拉伯女性的骨矿含量低于白种女性，且总骨面积和小梁面积也较小。在胫骨4%处，阿拉伯女性的总体积骨密度低于南亚女性。阿拉伯女性（36.5(22.4标准差)）和南亚女性（31.4(16.8标准差)）的血清25(OH)D水平显著低于白种女性（81.9(20.0标准差)）（P<0.05）。在任何种族组中，25(OH)D与pQCT骨变量之间均无统计学显著相关性。

结论

本研究表明，绝经前阿拉伯女性可能需要关注骨骼健康，同时阿拉伯和南亚人群的维生素D状况也有待改善。