Lee J H, Lee S S, Park J H, Kim Y W, Yang M H
Department of Pathology, Kyung Hee University Hospital, Seoul, Korea.
J Korean Med Sci. 1994 Aug;9(4):281-8. doi: 10.3346/jkms.1994.9.4.281.
A high incidence of a T cell phenotype of sinonasal lymphomas in other Asian countries has been associated with a high incidence of Epstein Barr virus (EBV) infection. We analyzed 13 sinonasal and 18 Waldeyer's ring lymphomas for the prevalence of EBV encoded RNA (EBER) using a sensitive and specific in situ hybridization. In addition, we examined the relationship of histologic findings and immunophenotype as well as the location of the lymphomas to the presence of EBV. The EBER was detected in each of 12 sinonasal lymphomas with a T cell immunophenotype. One B cell sinonasal lymphoma was EBER negative. Four of 18 Waldeyer's ring lymphomas were positive for EBER, including two T cell lymphomas. Two of 16 B cell Waldeyer's ring lymphomas were EBER positive. Morphologically, 11 of 20 diffuse large cell lymphomas, 2 diffuse mixed small and large cell lymphomas, 2 of 4 immunoblastic lymphomas and 1 lymphoplasmacytic lymphoma were EBER positive. Four follicular large cell lymphomas were EBER negative. A characteristic angiocentric or angiodestructive pattern was found in most T cell lymphomas and EBER positive cases. These findings indicate that EBV infection is more strongly associated with the T cell immunophenotype, angiocentric pattern and sinonasal location of the lymphoma.
在其他亚洲国家，鼻窦淋巴瘤的T细胞表型高发与爱泼斯坦-巴尔病毒（EBV）感染的高发生率相关。我们使用敏感且特异的原位杂交技术，分析了13例鼻窦淋巴瘤和18例咽淋巴环淋巴瘤中EBV编码RNA（EBER）的流行情况。此外，我们还研究了组织学表现、免疫表型以及淋巴瘤的位置与EBV存在之间的关系。在12例具有T细胞免疫表型的鼻窦淋巴瘤中均检测到了EBER。1例B细胞鼻窦淋巴瘤EBER阴性。18例咽淋巴环淋巴瘤中有4例EBER阳性，包括2例T细胞淋巴瘤。16例B细胞咽淋巴环淋巴瘤中有2例EBER阳性。形态学上，20例弥漫大细胞淋巴瘤中的11例、2例弥漫性混合小细胞和大细胞淋巴瘤、4例免疫母细胞淋巴瘤中的2例以及1例淋巴浆细胞淋巴瘤EBER阳性。4例滤泡大细胞淋巴瘤EBER阴性。在大多数T细胞淋巴瘤和EBER阳性病例中发现了特征性的血管中心性或血管破坏性模式。这些发现表明，EBV感染与淋巴瘤的T细胞免疫表型、血管中心性模式和鼻窦位置的关联更为密切。
