Stratingh Institute for Chemistry and Center for Systems Chemistry, University of Groningen, Nijenborgh 4, 9747 AG, Groningen, The Netherlands.
Angew Chem Int Ed Engl. 2010 Mar 29;49(14):2486-528. doi: 10.1002/anie.200904948.
Asymmetric catalysis with transition-metal complexes is the basis for a vast array of stereoselective transformations and has changed the face of modern synthetic chemistry. Key to this success has been the design of chiral ligands to control the regio-, diastereo-, and enantioselectivity. Phosphoramidites have emerged as a highly versatile and readily accessible class of chiral ligands. Their modular structure enables the formation of ligand libraries and easy fine-tuning for a specific catalytic reaction. Phosphoramidites frequently show exceptional levels of stereocontrol, and their monodentate nature is essential in combinatorial catalysis, where a ligand-mixture approach is used. In this Review, recent developments in asymmetric catalysis with phosphoramidites used as ligands are discussed, with a focus on the formation of carbon-carbon and carbon-heteroatom bonds.
手性过渡金属配合物的不对称催化是一系列立体选择性转化的基础，改变了现代合成化学的面貌。成功的关键在于设计手性配体来控制区域选择性、非对映选择性和对映选择性。磷酰胺类配体已成为一类高度通用且易于获得的手性配体。它们的模块化结构能够形成配体库，并易于针对特定的催化反应进行微调。磷酰胺类配体通常表现出出色的立体控制水平，其单齿性质在组合催化中至关重要，在组合催化中使用配体混合物方法。本文综述了磷酰胺类配体在手性催化中的最新进展，重点讨论了碳-碳键和碳-杂原子键的形成。
