不对称催化中的杂双齿磷配体：优势配体方法与组合策略。

Hybrid bidentate phosphorus ligands in asymmetric catalysis: privileged ligand approach vs. combinatorial strategies.

机构信息

Supramolecular & Homogeneous Catalysis Group, van 't Hoff Institute for Molecular Sciences, University of Amsterdam, Nieuwe Achtergracht 166, 1018 WV, Amsterdam, The Netherlands.

出版信息

Org Biomol Chem. 2011 Mar 21;9(6):1704-13. doi: 10.1039/c0ob00732c. Epub 2011 Jan 31.

DOI:10.1039/c0ob00732c

PMID:21283872

Abstract

In this perspective the development of chiral phosphorus ligands for asymmetric catalysis is discussed, with a special focus on hybrid bidentate phosphorus ligands, in particular phosphine-phosphoramidites. An attempt is made to compare privileged ligand and combinatorial approaches to ligand development--for which the class of phosphine-phosphoramidite ligands is well suited--highlighting differences, similarities and their complementary use.

摘要

在这篇观点文章中，我们讨论了手性磷配体在不对称催化中的发展，特别关注了混合双齿磷配体，尤其是膦-磷酰胺配体。我们尝试比较了手性配体和组合方法在手性配体开发中的应用——膦-磷酰胺配体非常适合这两种方法——突出了它们之间的差异、相似性及其互补性的应用。