Health Methodology Research Group, University of Manchester, Manchester Academic Health Science Centre, UK.
Epidemiol Infect. 2011 Mar;139(3):400-5. doi: 10.1017/S095026881000066X. Epub 2010 Mar 25.
We investigated the effect of social inequalities on the uptake of human papillomavirus (HPV) vaccination, combining data from a feasibility study conducted in 2007-2008 in 2817 secondary schoolgirls in two UK primary-care trusts, with census and child health records. Uptake was significantly lower in more deprived areas (P<0·001) and in ethnic minority girls (P=0·013). The relatively small proportion of parents who actively refused vaccination by returning a negative consent form were more likely to come from more advantaged areas (P<0·001). Non-responding parents were from more deprived (P<0·001) and ethnic minority (P=0·001) backgrounds. Girls who did not receive HPV vaccination were less likely to have received all their childhood immunizations particularly measles, mumps and rubella (MMR). Different approaches may be needed to maximize HPV vaccine uptake in engaged and non-responding parents, including ethnic-specific approaches for non-responders.
我们结合了 2007-2008 年在英国两个初级保健信托中对 2817 名女中学生进行的可行性研究的数据，以及人口普查和儿童健康记录，研究了社会不平等对人乳头瘤病毒（HPV）疫苗接种率的影响。在较贫困地区（P<0·001）和少数族裔女孩中（P=0·013），接种率明显较低。通过返回否定同意书而积极拒绝接种疫苗的家长比例相对较小，更有可能来自较富裕的地区（P<0·001）。未回复的家长来自贫困地区（P<0·001）和少数民族地区（P=0·001）。未接种 HPV 疫苗的女孩不太可能接受过所有儿童免疫接种，尤其是麻疹、腮腺炎和风疹（MMR）。对于参与和未参与的家长，可能需要采取不同的方法来最大限度地提高 HPV 疫苗接种率，包括针对未参与的家长的特定族裔方法。
