Królikowska Kinga, Kiślak Jakub, Orywal Karolina, Zajkowska Monika
Department of Population Medicine and Lifestyle Diseases Prevention, The Faculty of Medicine, Medical University of Białystok, 15-269 Białystok, Poland.
Department of Biochemical Diagnostics, Medical University of Bialystok, Waszyngtona 15A St., 15-269 Bialystok, Poland.
Int J Mol Sci. 2025 May 2;26(9):4336. doi: 10.3390/ijms26094336.
Prostate cancer is one of the most common malignancies in men and represents a major challenge for modern medicine. In recent years, there has been growing interest in the role of vitamins in the pathogenesis of this disease, as well as their potential impact on prevention and supportive treatment. Studies conducted so far suggest that certain vitamins may exhibit antioxidant and anti-inflammatory properties, thus supporting the immune response, which may influence cancer risk and treatment efficacy. This article aims to present the current state of knowledge on the role of vitamins in prostate cancer, focusing on their potential importance both in prevention and as an adjunct to therapy. Vitamins A, D, E, C, and B-group compounds may influence prostate cancer development and progression through mechanisms such as antioxidant activity, regulation of cell proliferation, apoptosis, and immune modulation. Despite promising insights from basic research, clinical studies remain inconclusive, and the effects of vitamin supplementation depend on factors like dosage, form, and individual variability. Therefore, a balanced diet rich in natural vitamins is recommended, while further research is needed to clarify their therapeutic and preventive roles in prostate cancer.
前列腺癌是男性最常见的恶性肿瘤之一,也是现代医学面临的一项重大挑战。近年来,人们越来越关注维生素在该疾病发病机制中的作用,以及它们对预防和支持性治疗的潜在影响。迄今为止进行的研究表明,某些维生素可能具有抗氧化和抗炎特性,从而支持免疫反应,这可能会影响癌症风险和治疗效果。本文旨在介绍关于维生素在前列腺癌中作用的当前知识状态,重点关注它们在预防和作为治疗辅助手段方面的潜在重要性。维生素A、D、E、C和B族化合物可能通过抗氧化活性、细胞增殖调节、细胞凋亡和免疫调节等机制影响前列腺癌的发生和发展。尽管基础研究有了有前景的见解,但临床研究仍无定论,维生素补充剂的效果取决于剂量、形式和个体差异等因素。因此,建议摄入富含天然维生素的均衡饮食,同时需要进一步研究以阐明它们在前列腺癌治疗和预防中的作用。