Yin Ming, Wei Sheng, Wei Qingyi
Departments of Epidemiology, The University of Texas, M. D. Anderson Cancer Center 1515 Holcombe Blvd, Houston, TX77030, USA.
Int J Clin Exp Med. 2009 Jun 15;2(2):159-75.
To update data on the role of vitamin D receptor (VDR) single nucleotide polymorphisms (SNPs) in susceptibility to prostate cancer, we performed a meta-analysis of 36 eligible publications on the association of Taql, Apal, Bsml, Fokl and CDX2 SNPs of the VDR gene with prostate cancer risk. Our study suggested that the Taql t and Bsml B alleles were associated with reduced prostate cancer risk among all study populations. Stratified analysis by ethnicity revealed that the Apal a allele was associated with reduced prostate cancer risk only among Asian populations, whereas the Fokl f allele showed a trend of increased prostate cancer risk only among Caucasian populations in a dominant model, independent of tumor stage (local or advanced). These results suggest that VDR polymorphisms may be potential biomarkers for prostate cancer susceptibility.
为了更新维生素D受体（VDR）单核苷酸多态性（SNP）在前列腺癌易感性中作用的数据，我们对36篇关于VDR基因的TaqI、ApaI、BsmI、FokI和CDX2 SNP与前列腺癌风险关联的合格出版物进行了荟萃分析。我们的研究表明，在所有研究人群中，TaqI t和BsmI B等位基因与降低前列腺癌风险相关。按种族进行的分层分析显示，仅在亚洲人群中，ApaI a等位基因与降低前列腺癌风险相关，而在显性模型中，仅在白种人群中，FokI f等位基因显示出前列腺癌风险增加的趋势，且与肿瘤分期（局部或晚期）无关。这些结果表明，VDR多态性可能是前列腺癌易感性的潜在生物标志物。
