维生素D受体基因多态性与前列腺癌风险：36项已发表研究的荟萃分析
Vitamin D Receptor Genetic Polymorphisms and Prostate Cancer Risk: A Meta-analysis of 36 Published Studies.
作者信息
Yin Ming, Wei Sheng, Wei Qingyi
机构信息
Departments of Epidemiology, The University of Texas, M. D. Anderson Cancer Center 1515 Holcombe Blvd, Houston, TX77030, USA.
出版信息
Int J Clin Exp Med. 2009 Jun 15;2(2):159-75.
Abstract
To update data on the role of vitamin D receptor (VDR) single nucleotide polymorphisms (SNPs) in susceptibility to prostate cancer, we performed a meta-analysis of 36 eligible publications on the association of Taql, Apal, Bsml, Fokl and CDX2 SNPs of the VDR gene with prostate cancer risk. Our study suggested that the Taql t and Bsml B alleles were associated with reduced prostate cancer risk among all study populations. Stratified analysis by ethnicity revealed that the Apal a allele was associated with reduced prostate cancer risk only among Asian populations, whereas the Fokl f allele showed a trend of increased prostate cancer risk only among Caucasian populations in a dominant model, independent of tumor stage (local or advanced). These results suggest that VDR polymorphisms may be potential biomarkers for prostate cancer susceptibility.
摘要
为了更新维生素D受体（VDR）单核苷酸多态性（SNP）在前列腺癌易感性中作用的数据，我们对36篇关于VDR基因的TaqI、ApaI、BsmI、FokI和CDX2 SNP与前列腺癌风险关联的合格出版物进行了荟萃分析。我们的研究表明，在所有研究人群中，TaqI t和BsmI B等位基因与降低前列腺癌风险相关。按种族进行的分层分析显示，仅在亚洲人群中，ApaI a等位基因与降低前列腺癌风险相关，而在显性模型中，仅在白种人群中，FokI f等位基因显示出前列腺癌风险增加的趋势，且与肿瘤分期（局部或晚期）无关。这些结果表明，VDR多态性可能是前列腺癌易感性的潜在生物标志物。
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