Grupo de Espectroscopía Molecular (GEM), Departamento de Química Física y Química Inorgánica, Facultad de Ciencias, Universidad de Valladolid, 47005 Valladolid, Spain.
Phys Chem Chem Phys. 2010 Apr 14;12(14):3573-8. doi: 10.1039/b926520a. Epub 2010 Mar 5.
The multiconformational landscape of the proteogenic amino acid aspartic acid, the simplest amino acid with two carboxylic groups, has been explored for the first time in the gas phase. Solid aspartic acid (m.p. > 300 degrees C) was vaporized by laser ablation and expanded in a supersonic jet where rotational spectra of various conformers were obtained by Fourier transform microwave spectroscopy. Six different conformers have been conclusively identified by their distinct rotational and (14)N nuclear quadrupole coupling constants. The relative stability of the conformers rests on a delicate balance of the different intramolecular hydrogen bonds established between the two carboxylic groups and the amino group.
首次在气相中探索了具有两个羧基的最简单氨基酸 - 生物生成氨基酸天冬氨酸的多构象景观。通过激光烧蚀将固态天冬氨酸（熔点> 300°C）蒸发，并在超音速射流中扩展，通过傅里叶变换微波光谱获得了各种构象体的旋转光谱。通过它们独特的旋转和（14）N 核四极耦合常数，已经确定了六个不同的构象体。构象体的相对稳定性取决于两个羧基和氨基之间建立的不同分子内氢键之间的微妙平衡。
