Alberta Health Services, 1331-29 St NW, Calgary, AB T2N 4N2, Canada.
Cancer Causes Control. 2010 Jul;21(7):1105-16. doi: 10.1007/s10552-010-9538-1. Epub 2010 Mar 25.
A population-based case-control study of physical activity and endometrial cancer risk was conducted in Alberta between 2002 and 2006. Incident, histologically confirmed cases of endometrial cancer (n = 542) were frequency age-matched to controls (n = 1,032). The Lifetime Total Physical Activity Questionnaire was used to measure occupational, household, and recreational activity levels. Multivariable logistic regression analyses were conducted. Total lifetime physical activity reduced endometrial cancer risk (odds ratio [OR] for >129 vs. <82 MET-h/week/year = 0.86, 95% confidence interval [95% CI]: 0.63, 1.18). By type of activity, the risks were significantly decreased for greater recreational activity (OR = 0.64, 95% CI: 0.47, 0.87), but not for household activity (OR = 1.09, 95% CI: 0.75, 1.58) and/or occupational activity (OR = 0.90, 95% CI: 0.67, 1.20) when comparing the highest to lowest quartiles. For activity performed at different biologically defined life periods, some indication of reduced risks with activity done between menarche and full-term pregnancy and after menarche was observed. When examining the activity by intensity of activity (i.e., light <3, moderate 3-6, and vigorous >6 METs), light activity slightly decreased endometrial cancer risk (OR = 0.68, 95% CI: 0.48, 0.97) but no association with moderate or vigorous intensity activity was found. Endometrial cancer risk was increased with sedentary occupational activity by 28% (95 CI%: 0.89, 1.83) for >11.3 h/week/year versus <or=2.4 h/week/year or by 11% for every 5 h/week/year spent in sedentary behavior. This study provides evidence for a decreased risk between lifetime physical activity and endometrial cancer risk and a possible increased risk associated with sedentary behavior.
一项基于人群的病例对照研究于 2002 年至 2006 年在艾伯塔省进行，研究了体力活动与子宫内膜癌风险的关系。本研究将经组织学证实的子宫内膜癌病例（n=542）与年龄匹配的对照组（n=1032）进行了频率匹配。使用终生总体力活动问卷来衡量职业、家庭和娱乐活动水平。进行了多变量逻辑回归分析。总的终生体力活动降低了子宫内膜癌的风险（与>129 与<82MET-h/week/year 相比，比值比[OR]为 0.86，95%置信区间[95%CI]：0.63，1.18）。按活动类型，剧烈娱乐活动的风险显著降低（OR=0.64，95%CI：0.47，0.87），而家务活动（OR=1.09，95%CI：0.75，1.58）和/或职业活动（OR=0.90，95%CI：0.67，1.20）的风险未见明显降低。对于在不同生物学定义的生命时期进行的活动，观察到在月经初潮和足月妊娠之间以及月经初潮后进行的活动与风险降低之间存在一些关联。当检查按活动强度（即轻度<3、中度 3-6 和剧烈>6 METs）进行的活动时，轻度活动略微降低了子宫内膜癌的风险（OR=0.68，95%CI：0.48，0.97），但与中度或剧烈强度活动无关。与每周从事<2.4 小时或每周从事>11.3 小时的久坐职业活动相比，每周从事>11.3 小时的职业活动会使子宫内膜癌风险增加 28%（95%CI%：0.89，1.83），而每周从事>5 小时的久坐行为则会使子宫内膜癌风险增加 11%。本研究提供了证据表明终生体力活动与子宫内膜癌风险之间存在降低风险的关系，并且与久坐行为相关联可能会增加风险。
