Friedenreich C M, McGregor S E, Courneya K S, Angyalfi S J, Elliott F G
Division of Population Health and Information, Alberta Cancer Board, Calgary, Alberta, Canada.
Am J Epidemiol. 2004 Apr 15;159(8):740-9. doi: 10.1093/aje/kwh106.
A population-based case-control study of physical activity and prostate cancer risk was conducted in Alberta, Canada, between 1997 and 2000. A total of 988 incident, histologically confirmed cases of stage T2 or greater prostate cancer were frequency matched to 1,063 population controls. The Lifetime Total Physical Activity Questionnaire was used to measure occupational, household, and recreational activity levels from childhood until diagnosis. Multivariable logistic regression analyses were conducted. No association for total lifetime physical activity and prostate cancer risk was found (odds ratio (OR) for > or =203 vs. <115 metabolic equivalent-hours/week/year=0.87, 95% confidence interval (CI): 0.65, 1.17). By type of activity, the risks were decreased for occupational (OR=0.90, 95% CI: 0.66, 1.22) and recreational (OR=0.80, 95% CI: 0.61, 1.05) activity but were increased for household (OR=1.36, 95% CI: 1.05, 1.76) activity when comparing the highest and lowest quartiles. For activity performed at different age periods throughout life, activity done during the first 18 years of life (OR=0.78, 95% CI: 0.59, 1.04) decreased risk. When activity was examined by intensity of activity (i.e., low, <3; moderate, 3-6; and vigorous, >6 metabolic equivalents), vigorous activity decreased prostate cancer risk (OR=0.70, 95% CI: 0.54, 0.92). This study provides inconsistent evidence for the association between physical activity and prostate cancer risk.
1997年至2000年期间，在加拿大艾伯塔省开展了一项基于人群的身体活动与前列腺癌风险的病例对照研究。总共988例经组织学确诊的T2期或更晚期前列腺癌新发病例，与1063名人群对照进行了频数匹配。使用《终生总体身体活动问卷》来测量从童年到确诊期间的职业、家庭和娱乐活动水平。进行了多变量逻辑回归分析。未发现终生总体身体活动与前列腺癌风险之间存在关联（≥203与<115代谢当量小时/周/年相比的优势比（OR）=0.87，95%置信区间（CI）：0.65，1.17）。按活动类型划分，在比较最高和最低四分位数时，职业活动（OR=0.90，95%CI：0.66，1.22）和娱乐活动（OR=0.80，95%CI：0.61，1.05）的风险降低，但家庭活动（OR=1.36，95%CI：1.05，1.76）的风险增加。对于一生中不同年龄段进行的活动，生命最初18年进行的活动（OR=0.78，95%CI：0.59，1.04）降低了风险。当按活动强度（即低强度，<3；中等强度，3 - 6；高强度，>6代谢当量）检查活动时，高强度活动降低了前列腺癌风险（OR=0.70，95%CI：0.54，0.92）。这项研究为身体活动与前列腺癌风险之间的关联提供了不一致的证据。
