University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
J Clin Exp Neuropsychol. 2010 Oct;32(8):836-46. doi: 10.1080/13803391003596389. Epub 2010 Mar 24.
This study investigated the effects of endocrine therapy (i.e., tamoxifen and anastrozole) on cognitive functioning by comparing 28 postmenopausal women with breast cancer to 37 healthy age-equivalent controls. Participants completed neuropsychological tests previously shown to be estrogen sensitive (e.g., verbal memory, letter fluency). A significant treatment effect was observed on speeded measures of letter fluency, complex visuomotor attention, and manual dexterity, but not on measures of verbal or object-location memory, or on tests presumed to be estrogen insensitive (e.g., spatial ability). In partial support of previous research, these results indicate that endocrine therapy can have detrimental effects on speeded higher brain functions but not necessarily on memory.
本研究通过比较 28 名绝经后患有乳腺癌的女性和 37 名年龄匹配的健康对照组，调查了内分泌治疗（即他莫昔芬和阿那曲唑）对认知功能的影响。参与者完成了先前被证明对雌激素敏感的神经心理学测试（例如，语言记忆，字母流畅性）。在字母流畅性、复杂视动注意力和手灵巧性的速度测量上观察到显著的治疗效果，但在语言或物体位置记忆的测量上或在被认为对雌激素不敏感的测试上（例如，空间能力）则没有观察到治疗效果。部分支持先前的研究结果，这些结果表明内分泌治疗可能对快速的高级大脑功能产生不利影响，但不一定对记忆有影响。
