5-羟色胺转运体基因多态性与原发性失眠的关系。
Association between a serotonin transporter length polymorphism and primary insomnia.
机构信息
Central Institute of Mental Health, Department of Psychiatry and Psychotherapy, Mannheim, Germany.
出版信息
Sleep. 2010 Mar;33(3):343-7. doi: 10.1093/sleep/33.3.343.
Abstract
STUDY OBJECTIVE
To test the hypothesis that a 44-base-pair insertion/deletion polymorphism in the 5' regulatory region of the serotonin transporter gene (5-HTTLPR) is associated with primary insomnia.
DESIGN
Association study.
SETTING
Sleep laboratory at the Central Institute of Mental Health, Mannheim, Germany.
PATIENTS
157 patients with primary insomnia and 827 healthy controls.
INTERVENTIONS
N/A.
MEASUREMENT AND RESULTS
We found the short (s-) allele of the 5-HTTLPR to be significantly more frequent in patients suffering from insomnia than in control individuals (47.1% vs. 39.9%: OR = 1.34).
CONCLUSIONS
This finding contributes to the understanding of the pathophysiology of primary insomnia and suggests a biological basis between the prevalent comorbidity of primary insomnia and other psychiatric disorders.
摘要
研究目的
检验 5-羟色胺转运体基因（5-HTTLPR）5'调控区 44 个碱基对插入/缺失多态性与原发性失眠相关的假设。
研究设计
关联研究。
研究地点
德国曼海姆中央心理卫生研究所睡眠实验室。
研究对象
157 例原发性失眠患者和 827 例健康对照者。
干预措施
无。
测量和结果
我们发现原发性失眠患者中短（s-）等位基因的频率明显高于对照组（47.1%比 39.9%：OR=1.34）。
结论
这一发现有助于理解原发性失眠的病理生理学，并提示原发性失眠与其他精神障碍普遍共病之间存在生物学基础。
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