Hwang Jong Ha, Lee Jae Kwan, Lee Nak Woo, Lee Kyu Wan
Department of Obstetrics and Gynecology, College of Medicine, Korea University, Seoul.
J Reprod Med. 2010 Jan-Feb;55(1-2):81-6.
Small cell carcinoma (SCC) is a well-known tumor that occurs predominantly in the lung. These tumors may also occur in the female genital tract, where it occurs most commonly in the cervix. Primary SCC of the endometrium is extremely rare. We report a case of an endometrial tumor that was a combination of an SCC and endometrioid adenocarcinoma with squamous components and that penetrated half of the thickness of the uterine wall.
A 59-year-old, postmenopausal woman suffering from postmenopausal bleeding presented for care. The patient underwent a total abdominal hysterectomy, bilateral salpingo-oophorectomy, and pelvic and paraaortic lymph node dissection, followed by concurrent chemoradiotherapy. Immunohistochemical studies showed neuroendocrine differentiation with positive CD 56, chromogranin and synaptophysin markers.
Immunohistochemical analyses are helpful in diagnosing and differentiating primary SCC of the endometrium from benign and malignant diseases of the endometrium.
小细胞癌（SCC）是一种主要发生于肺部的常见肿瘤。这些肿瘤也可能发生于女性生殖道，最常见于宫颈。子宫内膜原发性小细胞癌极为罕见。我们报告一例子宫内膜肿瘤，它是小细胞癌与具有鳞状成分的子宫内膜样腺癌的组合，且侵及子宫壁厚度的一半。
一名59岁绝经后女性因绝经后出血前来就诊。患者接受了全腹子宫切除术、双侧输卵管卵巢切除术以及盆腔和腹主动脉旁淋巴结清扫术，随后进行同步放化疗。免疫组化研究显示神经内分泌分化，CD 56、嗜铬粒蛋白和突触素标记物呈阳性。
免疫组化分析有助于诊断子宫内膜原发性小细胞癌，并将其与子宫内膜的良性和恶性疾病相鉴别。
