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子宫内膜原发性小细胞神经内分泌癌。

Primary small cell neuroendocrine carcinoma of the endometrium.

作者信息

Abaid Lisa N, Cupp John S, Brown John V, Goldstein Bram H

机构信息

Gynecologic Oncology Associates, Hoag Memorial Hospital Presbyterian, Newport Beach, Calif., USA.

出版信息

Case Rep Oncol. 2012 May;5(2):439-43. doi: 10.1159/000342006. Epub 2012 Aug 9.

DOI:10.1159/000342006
PMID:22949907
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3433003/
Abstract

BACKGROUND

Small cell neuroendocrine carcinoma is very rarely encountered within the endometrium.

CASE STUDY

A patient underwent a hysterectomy and salpingo-oophorectomy for a suspicious gynecologic condition. Pathology revealed invasive small cell neuroendocrine carcinoma of the endometrium; the neoplasm exhibited positive immunoreactivity for synaptophysin, pancytokeratin and CD56 but was negative for CD3 and CD20. Prior to chemotherapy, a completion lymphadenectomy was indicated to determine the presence of nodal metastases.

CONCLUSION

The prognosis of small cell neuroendocrine carcinoma of the endometrium is unfavorable but prompt detection with surgery and adjuvant therapy may confer a better clinical outcome.

摘要

背景

子宫内膜小细胞神经内分泌癌极为罕见。

病例研究

一名患者因可疑妇科疾病接受了子宫切除术和输卵管卵巢切除术。病理显示为子宫内膜浸润性小细胞神经内分泌癌；该肿瘤突触素、全细胞角蛋白和CD56免疫反应呈阳性，但CD3和CD20呈阴性。化疗前，建议行根治性淋巴结清扫术以确定是否存在淋巴结转移。

结论

子宫内膜小细胞神经内分泌癌预后不佳，但通过手术和辅助治疗及时发现可能带来更好的临床结果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a26a/3433003/d882f8e0d568/cro-0005-0439-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a26a/3433003/a16a0b5cadcc/cro-0005-0439-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a26a/3433003/d882f8e0d568/cro-0005-0439-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a26a/3433003/a16a0b5cadcc/cro-0005-0439-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a26a/3433003/d882f8e0d568/cro-0005-0439-g02.jpg

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本文引用的文献

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Primary endometrial small cell carcinoma.
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J Reprod Med. 2010 Jan-Feb;55(1-2):81-6.
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Small-cell carcinoma of the endometrium presenting as Cushing's syndrome.子宫内膜小细胞癌表现为库欣综合征。
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Small cell neuroendocrine carcinoma of the endometrium and laparoscopic staging: a clinicopathologic study of a case and a brief review of the literature.子宫内膜小细胞神经内分泌癌与腹腔镜分期：1例临床病理研究及文献简要回顾
Int J Gynecol Cancer. 2008 Jul-Aug;18(4):838-43. doi: 10.1111/j.1525-1438.2007.01059.x. Epub 2007 Sep 14.
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Prognostic significance of synaptophysin in stage I of squamous carcinoma and adenocarcinoma of the lung.
Cancer. 2007 Oct 15;110(8):1776-81. doi: 10.1002/cncr.22985.
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Small cell carcinoma of the female genital tract.女性生殖道小细胞癌
Semin Oncol. 2007 Feb;34(1):57-63. doi: 10.1053/j.seminoncol.2006.10.028.
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