Mills Bernice A, Davis Peter G, Donath Susan M, Clucas Luisa M, Doyle Lex W
Division of Newborn Services, The Royal Women's Hospital, Melbourne, Australia.
J Paediatr Child Health. 2010 May;46(5):255-8. doi: 10.1111/j.1440-1754.2009.01680.x. Epub 2010 Mar 22.
To determine if participation in a randomised controlled trial of different oxygen saturation targets improved compliance with oximeter alarm limit guidelines.
Eligible infants were born after the commencement of the BOOST II trial. Data on alarm limits were collected on all infants <32 weeks' gestational age or birth weight <1500 g, who were born at The Royal Women's Hospital, Melbourne between February and June 2007, and receiving supplemental oxygen at the time of the audit. The proportions of infants in oxygen with correct alarm limits (upper 94%; lower 85% or 86%) were compared, between those in the BOOST II trial and those who were not, and with an earlier audit.
Of 100 infants surveyed, 56 had received oxygen (mean gestational age at birth 26.7 weeks, mean birth weight 913 g). Compliance with lower limits was good in both periods, irrespective of post-menstrual age or participation in the trial. Compliance with upper limits improved after trial commencement, but only for infants enrolled in the trial and only whilst they were <36 weeks' post-menstrual age.
Starting a clinical trial of oxygen targeting was associated with improved compliance with upper alarm limits for participants receiving supplemental oxygen, but only whilst they were <36 weeks; with little effect outside the trial.
确定参与不同氧饱和度目标的随机对照试验是否能提高对血氧饱和度仪报警限值指南的依从性。
符合条件的婴儿在BOOST II试验开始后出生。收集了2007年2月至6月在墨尔本皇家妇女医院出生、胎龄<32周或出生体重<1500g、且在审核时接受补充氧气的所有婴儿的报警限值数据。比较了BOOST II试验中的婴儿和未参与试验的婴儿以及与早期审核相比,血氧饱和度处于正确报警限值(上限94%;下限85%或86%)的婴儿比例。
在接受调查的100名婴儿中,56名接受过氧气治疗(出生时平均胎龄26.7周,平均出生体重913g)。在两个时期,无论月经后年龄或是否参与试验,对下限的依从性都很好。试验开始后,对上限的依从性有所提高,但仅针对参与试验的婴儿,且仅在他们月经后年龄<36周时。
开始一项氧目标临床试验与接受补充氧气的参与者对上限报警限值的依从性提高有关,但仅在他们<36周时如此;在试验之外几乎没有效果。