CNR Neuroscience Institute, Viale Diaz 182, I-09126 Cagliari, Italy.
Br J Nutr. 2010 Sep;104(5):624-8. doi: 10.1017/S0007114510001017. Epub 2010 Mar 26.
Extracts from or derivatives of Phaseolus vulgaris beans reduce body weight and food intake, including highly palatable foods and fluids, in multiple rodent models of overeating and obesity. The present study was designed to assess whether a standardised P. vulgaris dry extract was effective in reducing also the operant self-administration of a chocolate-flavoured beverage. To this end, rats were initially trained to lever-press for a chocolate-flavoured beverage under a fixed ratio 10 schedule of reinforcement in daily 60 min sessions. Once lever-responding reached stable levels, the effect of a P. vulgaris dry extract on the number of lever-responses for the chocolate-flavoured beverage was determined. Pretreatment with 50, 200 and 500 mg (intragastric) P. vulgaris dry extract per kg produced an approximate 15, 35 and 40 % reduction, respectively, in lever-responding for the chocolate-flavoured beverage. These results indicate the capacity of a P. vulgaris preparation to reduce the reinforcing properties of a highly palatable fluid in rats.
菜豆提取物可降低体重和食物摄入量，包括多种暴食和肥胖的啮齿动物模型中的高适口性食物和液体。本研究旨在评估标准化菜豆干提取物是否也能有效减少巧克力味饮料的操作性自我给药。为此，大鼠最初在每日 60 分钟的时间段内接受强化固定比率 10 方案训练，以按压巧克力味饮料的杠杆。一旦杠杆反应达到稳定水平，就确定菜豆干提取物对巧克力味饮料的杠杆反应次数的影响。预处理 50、200 和 500mg（胃内）菜豆干提取物/ kg 分别产生了约 15%、35%和 40%的巧克力味饮料的杠杆反应减少。这些结果表明，菜豆制剂具有降低大鼠高适口性液体的强化特性的能力。
