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lipid-lowering formula alleviates fat and lipid accumulation by modulating gut microbiota and short-chain fatty acids in high-fat diet mice.

作者信息

Wang Gangzheng, Sun Chengyuan, Xie Bojun, Wang Tao, Liu Hongwei, Chen Xianglian, Huang Qiuju, Zhang Chenghua, Li Taihui, Deng Wangqiu

机构信息

Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, State Key Laboratory of Applied Microbiology Southern China, Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou, China.

State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.

出版信息

Front Nutr. 2022 Nov 2;9:1038740. doi: 10.3389/fnut.2022.1038740. eCollection 2022.

DOI:10.3389/fnut.2022.1038740
PMID:36407511
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9667106/
Abstract

Obesity has caused serious health and economic problems in the world. is a high-value macrofungus with broad application potential in the food and bio-medicine industry. This current study aimed to estimate the role of lipid-lowering compound formula (CGLC) in regulating fat and lipid accumulation, gut microbiota balance, short-chain fatty acid (SCFA) contents, and expression levels of genes involved in fat and lipid metabolism in high-fat diet (HFD) mice. The results showed that CGLC intervention markedly reduced body weights and fat accumulation in HFD mice, improved glucose tolerance and blood lipid levels, and decreased lipid droplet accumulation and fat vacuole levels in the liver. CGLC decreased the ratio of Firmicutes and Bacteroidetes and increased the relative abundances of () and (). In addition, CGLC treatment significantly promoted the production of SCFAs and regulated the relative expression levels of genes involved in fat and lipid metabolism in liver. Association analysis showed that several species of and most of SCFAs were significantly associated with serum lipid indicators. These results suggested that CGLC is a novel candidate formulation for treating obesity and non-alcohol fatty liver by regulating gut microbiota, SCFAs, and genes involved in fat and lipid metabolism.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cd3/9667106/5e5f1bc58ce3/fnut-09-1038740-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cd3/9667106/92ba7b6aeefe/fnut-09-1038740-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cd3/9667106/7c452da4857e/fnut-09-1038740-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cd3/9667106/39ec7b5b63db/fnut-09-1038740-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cd3/9667106/8ad69d7fcb2f/fnut-09-1038740-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cd3/9667106/4dafc81ef6af/fnut-09-1038740-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cd3/9667106/7e847d08099f/fnut-09-1038740-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cd3/9667106/5e5f1bc58ce3/fnut-09-1038740-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cd3/9667106/92ba7b6aeefe/fnut-09-1038740-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cd3/9667106/7c452da4857e/fnut-09-1038740-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cd3/9667106/39ec7b5b63db/fnut-09-1038740-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cd3/9667106/8ad69d7fcb2f/fnut-09-1038740-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cd3/9667106/4dafc81ef6af/fnut-09-1038740-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cd3/9667106/7e847d08099f/fnut-09-1038740-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cd3/9667106/5e5f1bc58ce3/fnut-09-1038740-g007.jpg

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[3]
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[4]
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[5]
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[6]
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[7]
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[8]
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[9]
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[10]
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本文引用的文献

[1]
Polysaccharides from Lyophyllum decastes reduce obesity by altering gut microbiota and increasing energy expenditure.

Carbohydr Polym. 2022-11-1

[2]
Alleviates Obesity by Altering the Composition of the Gut Microbiota in High-Fat Diet-Fed Mice.

Front Nutr. 2022-6-30

[3]
Obesity-Related Chronic Kidney Disease: Principal Mechanisms and New Approaches in Nutritional Management.

Front Nutr. 2022-6-24

[4]
Effects of Different Green Teas on Obesity and Non-Alcoholic Fatty Liver Disease Induced by a High-Fat Diet in Mice.

Front Nutr. 2022-6-24

[5]
GOS Ameliorates Nonalcoholic Fatty Liver Disease Induced by High Fat and High Sugar Diet through Lipid Metabolism and Intestinal Microbes.

Nutrients. 2022-7-1

[6]
Thinned peach polyphenols alleviate obesity in high fat mice by affecting gut microbiota.

Food Res Int. 2022-7

[7]
Sanghuang Tongxie Formula Ameliorates Insulin Resistance in Through Regulating PI3K/Akt Signaling.

Front Pharmacol. 2022-6-6

[8]
The Methanol Extract of Ameliorates Colitis by Improving Intestinal Short-Chain Fatty Acids and Gas Production to Regulate Microbiota Dysbiosis in Mice.

Front Nutr. 2022-5-12

[9]
Crude Polysaccharide Extracted From Leaves Prevents Obesity in Association With Modulating Gut Microbiota in High-Fat Diet-Fed Mice.

Front Nutr. 2022-4-25

[10]
Regulation of gut microbiota and intestinal metabolites by Poria cocos oligosaccharides improves glycolipid metabolism disturbance in high-fat diet-fed mice.

J Nutr Biochem. 2022-9

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