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韩国分离的产毒 A 阴性、产毒 B 阳性艰难梭菌变异株的分子特征。

Molecular characterization of toxin A-negative, toxin B-positive variant strains of Clostridium difficile isolated in Korea.

机构信息

Department of Laboratory Medicine and Research Institute of Bacterial Resistance, Yonsei University College of Medicine, Seoul 120-752, Korea.

出版信息

Diagn Microbiol Infect Dis. 2010 Jun;67(2):198-201. doi: 10.1016/j.diagmicrobio.2010.01.007. Epub 2010 Mar 24.

DOI:10.1016/j.diagmicrobio.2010.01.007
PMID:20338708
Abstract

A(-)B(+)Clostridium difficile strains are prevalent in Korea. We performed pulsed-field gel electrophoresis (PFGE), polymerase chain reaction ribotyping, and toxinotyping in 82 A(-)B(+) clinical isolates in Korea. PFGE showed highest discriminatory capability among the 3 methods. By PFGE, persistence of a clone was found, suggesting this clone has adapted to the hospital environment.

摘要

韩国流行 A(-)B(+)艰难梭菌菌株。我们对韩国 82 株 A(-)B(+)临床分离株进行了脉冲场凝胶电泳（PFGE）、聚合酶链反应核糖体分型和毒素定型。PFGE 在这 3 种方法中显示出最高的分辨能力。通过 PFGE，发现了一个克隆的持续存在，表明这个克隆已经适应了医院环境。

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