Clostridia Research Group, Centre for Biomolecular Sciences, School of Molecular Medical Sciences, University of Nottingham, Nottingham NG7 2RD, UK.
Gut Microbes. 2011 Jul-Aug;2(4):252-5. doi: 10.4161/gmic.2.4.16109. Epub 2011 Jul 1.
The bacterium is the leading cause of healthcare associated diarrhoea in the developed world and thus presents a major financial burden. The main virulence factors of are two large toxins, A and B. Over the years there has been some debate over the respective roles and importance of these two toxins. To address this, we recently constructed stable toxin mutants of and found that they were virulent if either toxin A or toxin B was functional. This underlined the importance of each toxin and the necessity to consider both when developing countermeasures against infection (CDI). In this article we discuss our findings in the context of previous work and outline some of the challenges which face the field as a result.
这种细菌是发达国家医疗保健相关性腹泻的主要病原体，因此给医疗保健带来了巨大的经济负担。的主要毒力因子是两种大型毒素，A 和 B。多年来，这两种毒素的相对作用和重要性一直存在争议。为了解决这个问题，我们最近构建了的稳定毒素突变体，发现只要毒素 A 或毒素 B 具有功能，它们就是有毒的。这突出了每种毒素的重要性，并且在开发针对感染（CDI）的对策时，有必要同时考虑这两种毒素。在本文中，我们将根据以前的工作讨论我们的发现，并概述该领域目前面临的一些挑战。
