Transylvania University, Faculty of Medicine, Department of Allergy and Clinical Immunology; B-ul Eroilor 29, Brasov 500036, Romania.
Respir Med. 2010 Aug;104(8):1131-7. doi: 10.1016/j.rmed.2010.02.018. Epub 2010 Mar 24.
IL-17 expression was found to be associated with many inflammatory diseases in humans, such as rheumatoid arthritis, asthma, systemic lupus erythematosus and allograft rejection and many in vitro studies have indicated a proinflammatory function for IL-17.
Prognostic value of increased serum IL-17 in asthma patients.
Serum IL-17 (ELISA) was measured in 85 asthma patients (pts), mean age 46.99 +/- 14.1 years, 61% females, 23 mild persistent, 26 moderate persistent and 36 severe persistent asthma. Using multiple regression analysis (STATISTICA 7), increased serum IL-17 (>20 pg/ml) was tested as risk factor for severe asthma in comparison with "traditional" risk factors: smoke, NSAID intolerance, obesity, chronic rhinosinusitis, blood eosinophilia, FEV(1) at baseline < 50% predicted (low FEV(1)).
Medium serum IL-17 values were 14.21 pg/ml in mild asthma, 12.22 pg/ml in moderate asthma and 24.72 pg/ml in severe asthma. IL-17 values > 20 pg/ml were encountered in 3(13%) mild asthma pts (p < 0.001 vs. severe asthma), 2(8%) moderate asthma pts. (p < 0.001 vs. severe asthma), and in 11(31%) severe asthma pts. For severe asthma multiple regression analysis revealed as independent risk factors IL-17 (p = 0.000290), NSAID intolerance (p = 0.000585) and low FEV(1) (p = 0.000059).
IL-17 is increased in severe asthma compared to mild/moderate forms of the disease and values above 20 pg/ml are an independent risk factor for severe asthma.
IL-17 的表达与人类的许多炎症性疾病有关，如类风湿性关节炎、哮喘、系统性红斑狼疮和同种异体移植排斥等。许多体外研究表明 IL-17 具有促炎作用。
哮喘患者血清中 IL-17 升高的预后价值。
测定 85 例哮喘患者（pts）血清 IL-17（ELISA），平均年龄 46.99±14.1 岁，女性占 61%，23 例轻度持续性哮喘，26 例中度持续性哮喘，36 例重度持续性哮喘。采用多元回归分析（STATISTICA 7），与“传统”危险因素（吸烟、非甾体抗炎药不耐受、肥胖、慢性鼻-鼻窦炎、血嗜酸性粒细胞计数升高、基线时 FEV1<50%预计值（低 FEV1））相比，检测血清中升高的 IL-17（>20pg/ml）是否为重度哮喘的危险因素。
轻度哮喘、中度哮喘和重度哮喘患者的血清 IL-17 中位数分别为 14.21pg/ml、12.22pg/ml 和 24.72pg/ml。在 3 例（13%）轻度哮喘患者（与重度哮喘比较，p<0.001）、2 例（8%）中度哮喘患者（与重度哮喘比较，p<0.001）和 11 例（31%）重度哮喘患者中发现 IL-17 值>20pg/ml。多元回归分析显示，对于重度哮喘，IL-17（p=0.000290）、非甾体抗炎药不耐受（p=0.000585）和低 FEV1（p=0.000059）是独立的危险因素。
与轻度/中度哮喘相比，重度哮喘患者的 IL-17 升高，IL-17 值>20pg/ml 是重度哮喘的独立危险因素。
