Bacterial Resistance Monitoring Center of Anhui Province, Hefei, Anhui, PR China.
Department of Infectious Diseases, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, PR China.
J Med Microbiol. 2010 Jul;59(Pt 7):843-847. doi: 10.1099/jmm.0.016337-0. Epub 2010 Mar 25.
Aeromonas species rarely cause pulmonary infection. We report, for what is believed to be the first time, a case of severe pneumonia in a cancer patient caused by Aeromonas caviae. Detailed microbiological investigation revealed that this isolate carried three beta-lactamase-encoding genes (encoding MOX-4, CTX-M-3 and TEM-1) conferring resistance to all beta-lactams but imipenem. The beta-lactamase with a pI of 9.0 was transferred by conjugation and associated with a 7.3 kb plasmid, as demonstrated by Southern blot hybridization. Analysis of the nucleotide and amino acid sequences showed a new ampC gene that was closely related to those encoding the MOX-1, MOX-2 and MOX-3 beta-lactamases. This new plasmid-mediated AmpC beta-lactamase from China was named MOX-4. This is believed to be the first report of MOX-4, CTX-M-3 and TEM-1 beta-lactamases in a multiresistant A. caviae.
气单胞菌属很少引起肺部感染。我们报告了首例由豚鼠气单胞菌引起的癌症患者重症肺炎，据信这是首次报告。详细的微生物学调查显示，该分离株携带三个β-内酰胺酶编码基因（编码 MOX-4、CTX-M-3 和 TEM-1），对所有β-内酰胺类药物但亚胺培南具有耐药性。pI 为 9.0 的β-内酰胺酶通过共轭转移，并与 7.3 kb 质粒相关，如 Southern 印迹杂交所示。核苷酸和氨基酸序列分析显示了一个新的 AmpC 基因，与编码 MOX-1、MOX-2 和 MOX-3 β-内酰胺酶的基因密切相关。这种来自中国的新型质粒介导的 AmpC β-内酰胺酶被命名为 MOX-4。这被认为是首次在多药耐药的豚鼠气单胞菌中发现 MOX-4、CTX-M-3 和 TEM-1 β-内酰胺酶。
