来自希腊的肺炎克雷伯菌中新型质粒编码的C类β-内酰胺酶（MOX-2）
Novel plasmid-encoded class C beta-lactamase (MOX-2) in Klebsiella pneumoniae from Greece.
作者信息
Raskine Laurent, Borrel Isabelle, Barnaud Guilène, Boyer Sophie, Hanau-Berçot Béatrice, Gravisse Jérome, Labia Roger, Arlet Guillaume, Sanson-Le-Pors Marie-José
机构信息
Service de Bacteriologie-Virologie, Hôpital Lariboisière, Assistance Publique-Hôpitaux de Paris, 75475 Paris Cedex 10, France.
出版信息
Antimicrob Agents Chemother. 2002 Jul;46(7):2262-5. doi: 10.1128/AAC.46.7.2262-2265.2002.
Abstract
Klebsiella pneumoniae KOL, a clinical strain resistant to various beta-lactams, was isolated from the stools of a patient from Greece. This strain harbored a new pI 9.1 plasmid-mediated AmpC beta-lactamase with unusually high levels of hydrolytic activity for cefoxitin and cefotetan that we named MOX-2. Sequencing of bla(MOX-2) revealed 93.2, 92.9, 92.7, and 73.1% identities with the deduced amino acid sequences of CMY-8, MOX-1, CMY-1, and the AmpC beta-lactamase of Aeromonas sobria, respectively.
摘要
肺炎克雷伯菌KOL是从一名希腊患者粪便中分离出的对多种β-内酰胺类抗生素耐药的临床菌株。该菌株携带一种新的pI 9.1质粒介导的AmpCβ-内酰胺酶，对头孢西丁和头孢替坦具有异常高水平的水解活性，我们将其命名为MOX-2。bla(MOX-2)的测序结果显示，其推导的氨基酸序列与CMY-8、MOX-1、CMY-1以及温和气单胞菌的AmpCβ-内酰胺酶的氨基酸序列分别具有93.2%、92.9%、92.7%和73.1%的同一性。
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