Department of Family Medicine, University of Ulsan College of Medicine, Seoul, Korea.
Obesity (Silver Spring). 2010 Nov;18(11):2105-10. doi: 10.1038/oby.2010.60. Epub 2010 Mar 25.
Visceral adipose tissue-derived serpin (vaspin) has been regarded as a novel adipokine with potential insulin sensitizing properties. We investigated the changes of serum vaspin concentration in response to weight reduction, and the associations between changes in serum vaspin concentrations and changes of anthropometric and metabolic variables in obese subjects after weight reduction. We performed a longitudinal clinical intervention study on 63 obese persons enrolled in a 12-week weight reduction program that included lifestyle modification and adjuvant treatment with the antiobesity agent orlistat. Anthropometric variables, lipid profiles, fasting glucose, fasting insulin, and serum vaspin concentrations were measured. Statistical analyses were performed according to the homeostasis model assessment of insulin resistance (HOMA(IR)). Serum vaspin concentrations decreased significantly in responders (≥2% reduction in baseline weight), but not in nonresponders (<2% reduction in baseline weight). Changes in serum vaspin concentrations were significantly correlated with body weight, BMI, waist circumference, and hip circumference in the higher, but not in the lower, HOMA(IR) group. In multivariate linear regression analysis, change in serum vaspin concentrations in the higher, but not in the lower, HOMA(IR) group was positively correlated with change in BMI and negatively correlated with initial HOMA(IR) level. The associations between changes in serum vaspin concentrations and changes in anthropometric and metabolic parameters differed according to insulin resistance status in obese subjects. These relationships were more prominent in the higher HOMA(IR) group. Insulin resistance may influence the correlations between changes in serum vaspin concentration and related metabolic variables.
内脏脂肪组织来源的丝氨酸蛋白酶抑制剂（vaspin）被认为是一种具有潜在胰岛素增敏作用的新型脂肪因子。我们研究了肥胖患者在减肥后，血清 vaspin 浓度的变化，以及血清 vaspin 浓度的变化与人体测量学和代谢变量变化之间的关系。我们对 63 名肥胖患者进行了一项为期 12 周的减肥计划的纵向临床干预研究，该计划包括生活方式改变和辅助使用减肥药奥利司他。测量了人体测量学变量、血脂谱、空腹血糖、空腹胰岛素和血清 vaspin 浓度。根据稳态模型评估的胰岛素抵抗（HOMA(IR)）进行了统计分析。在应答者（体重较基线下降≥2%）中，血清 vaspin 浓度显著下降，但在非应答者（体重较基线下降<2%）中没有下降。血清 vaspin 浓度的变化与体重、BMI、腰围和臀围在较高的 HOMA(IR)组中呈显著相关，但在较低的 HOMA(IR)组中没有相关性。在多元线性回归分析中，较高的 HOMA(IR)组中，血清 vaspin 浓度的变化与 BMI 的变化呈正相关，与初始 HOMA(IR)水平呈负相关。血清 vaspin 浓度的变化与人体测量学和代谢参数的变化之间的关系因肥胖患者的胰岛素抵抗状态而异。在较高的 HOMA(IR)组中，这些关系更为明显。胰岛素抵抗可能影响血清 vaspin 浓度变化与相关代谢变量之间的相关性。
