Biochemistry Department, Faculty of Science, Ain Shams University, Cairo, Egypt.
Internal Medicine and Endocrinology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Obes Surg. 2018 Oct;28(10):3237-3245. doi: 10.1007/s11695-018-3306-9.
Cartonectin is a potent anti-inflammatory adipokine that might be implicated in metabolism and energy storage. Our objective was to evaluate the influence of weight reduction following laparoscopic sleeve gastrectomy (LSG) on serum cartonectin and vaspin levels.
Thirty-two individuals (29 female and 3 male) with morbid obesity underwent LSG. Anthropometric indices, lipid profile, fasting serum concentrations of glucose, insulin, vaspin, and cartonectin were measured prior and 3 months after LSG. Insulin sensitivity was determined using the homeostasis model assessment of insulin resistance (HOMA-IR).
Following LSG, circulating cartonectin level increased significantly while serum vaspin was significantly decreased. The percentage change of serum cartonectin level correlated negatively with the percentage changes in body mass index, waist circumference, and waist-hip ratio and positively with percentage changes in LDL-C, triglycerides, and HOMA-IR after adjustment for age and sex. Moreover, the changes in vaspin concentration positively correlated with the changes in insulin level and HOMA-IR after adjustment for age and sex. In a multiple stepwise linear regression model, the changes in waist circumference explained 13% variability of changes in cartonectin level while the changes in HOMA-IR and LDL-C were responsible for 31% of the variability in changes of vaspin level.
LSG-induced weight loss rapidly increases serum cartonectin level and decreases the serum vaspin level in morbidly obese subjects. The changes in cartonictin level seem to be influenced by the changes of waist circumference while the changes of HOMA-IR and LDL-C might be determinant factors of the changes in vaspin level.
Cartonectin 是一种强效的抗炎脂肪因子，可能与代谢和能量储存有关。我们的目的是评估腹腔镜袖状胃切除术（LSG）后体重减轻对血清 Cartonectin 和 Vaspin 水平的影响。
32 名肥胖患者（29 名女性和 3 名男性）接受了 LSG。术前和术后 3 个月测量了人体测量指数、血脂谱、空腹血糖、胰岛素、Vaspin 和 Cartonectin 血清浓度。使用稳态模型评估的胰岛素抵抗指数（HOMA-IR）来确定胰岛素敏感性。
LSG 后，循环 Cartonectin 水平显著升高，而血清 Vaspin 水平显著降低。血清 Cartonectin 水平的变化百分比与 BMI、腰围和腰臀比的变化百分比呈负相关，与 LDL-C、甘油三酯和 HOMA-IR 的变化百分比呈正相关，校正年龄和性别后。此外，Vaspin 浓度的变化与胰岛素水平和 HOMA-IR 的变化呈正相关，校正年龄和性别后。在多元逐步线性回归模型中，腰围的变化解释了 Cartonectin 水平变化的 13%，而 HOMA-IR 和 LDL-C 的变化解释了 Vaspin 水平变化的 31%。
LSG 诱导的体重减轻迅速增加肥胖患者的血清 Cartonectin 水平并降低血清 Vaspin 水平。Cartonectin 水平的变化似乎受腰围变化的影响，而 HOMA-IR 和 LDL-C 的变化可能是 Vaspin 水平变化的决定因素。
