Secoli Silvia Regina
Departamento de Enfermagem Médico-Cirúrgica, Escola de Enfermagem, Universidade de São Paulo.
Rev Bras Enferm. 2010 Jan-Feb;63(1):136-40. doi: 10.1590/s0034-71672010000100023.
The article has for objective to reflect on the polypharmacy of the aged with emphasis in the adverse drug reactions and the drug-drug interactions. The vulnerability of the elderly to the problems related from the use as of drugs is pretty upswing, the one to in case that must the complexity of the problems clinical, at the must as of need pharmacotherapeutic interventions, and to the update pharmacokinetic and pharmacodynamic changes inherent to the aging. In this way, to rationalize the drugs utilization and to avoid the injury related to the polypharmacy will be, doubtless, one of the biggest challenges for public health in this century.
本文旨在探讨老年人的多重用药问题，重点关注药物不良反应和药物相互作用。老年人因用药而出现相关问题的脆弱性正在显著上升，这是由于临床问题的复杂性、药物治疗干预的必要性以及衰老过程中固有的药代动力学和药效学变化。因此，合理用药并避免多重用药相关的伤害无疑将是本世纪公共卫生面临的最大挑战之一。
