Department of Surgery, Iizuka Hospital, 3-83 Yoshio-machi, Iizuka, Fukuoka, 820-8505, Japan.
Surg Today. 2010 Apr;40(4):376-9. doi: 10.1007/s00595-009-4078-6. Epub 2010 Mar 26.
Undifferentiated carcinomas with osteoclast-like giant cells are rare periampullary neoplasms, which morphologically mimic giant cell tumors of the bone. The terminology, histogenesis, biological behavior, and chemosensitivity of these tumors, and their treatment protocol, remain controversial. We report the case of a 71-year-old man with periampullary carcinoma who underwent pancreaticoduodenectomy under the diagnosis of periampullary carcinoma. Histologically, the neoplasm was composed of undifferentiated cells and evenly spaced osteoclast-like giant cells. Liver and paraaortic lymph node metastases were detected 6 months later and were treated effectively with intravenous gemcitabine. The patient remains in remission 2 years after surgery.
乏特氏壶腹周围癌伴破骨细胞样巨细胞是一种罕见的壶腹周围肿瘤，其形态学上类似于骨巨细胞瘤。这些肿瘤的术语、组织发生、生物学行为和化学敏感性以及治疗方案仍存在争议。我们报告了一例 71 岁男性患者，因壶腹周围癌行胰十二指肠切除术。组织学上，该肿瘤由未分化细胞和均匀分布的破骨细胞样巨细胞组成。6 个月后发现肝和腹主动脉旁淋巴结转移，并经静脉注射吉西他滨有效治疗。手术后 2 年，患者仍处于缓解期。
