Zubenkova E S, Kazymbetov P, Zaĭtsev A V
Med Radiol (Mosk). 1991;36(4):49-51.
The paper is concerned with some experimental data of a comparative study of the efficacy of a hypoxic mixture used for the protection of hemopoietic tissue in single and fractionated irradiation of animals. The protective effect was shown to be on the decrease in change from acute to fractionated irradiation during hypoxia. The use of two criteria of assessment (specific for the hemopoietic system--CFU-C and integral--50% the survival rate among animals 50%) confirmed the general direction of processes. Hypoxia used as a protector, resulted in a decrease in an effective irradiation dose, manifested in lesser affection of the hemopoietic stem cell pool and consequently in the proliferating bone marrow cell pool.
本文涉及关于一种用于保护动物单次和分次照射造血组织的低氧混合气疗效比较研究的一些实验数据。结果表明，在低氧状态下，从急性照射到分次照射，保护作用呈下降趋势。采用两种评估标准（一种是造血系统特异性的——集落形成单位 - 细胞（CFU - C），另一种是综合的——动物存活率达到50%时的50%存活率）证实了这些过程的总体趋势。用作保护剂的低氧状态导致有效照射剂量降低，表现为造血干细胞池受影响较小，进而骨髓增殖细胞池受影响也较小。
