体外筛选血红素光响应 RNA 适体。
In vitro selection of a photoresponsive RNA aptamer to hemin.
机构信息
Nano Medical Engineering Laboratory, RIKEN Advanced Science Institute, 2-1 Hirosawa, Wako-Shi, Saitama 351-0198, Japan.
出版信息
Bioorg Med Chem Lett. 2010 May 1;20(9):2964-7. doi: 10.1016/j.bmcl.2010.02.109. Epub 2010 Mar 3.
PMID:20347300
Abstract
A photoresponsive RNA aptamer to hemin was selected in vitro from a random sequence library of RNAs with azobenzene residues. The aptamer bound to hemin under visible light irradiation and was released by ultraviolet light.
摘要
从带有偶氮苯残基的随机 RNA 序列文库中体外筛选出了对血红素具有光响应的 RNA 适体。该适体在可见光照射下与血红素结合，并在紫外光照射下释放。
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