浅部真菌病的系统和局部治疗的现代概念。

Current concepts in systemic and topical therapy for superficial mycoses.

机构信息

Department of Dermatology, Tulane University School of Medicine, New Orleans, LA 70112, USA.

出版信息

Clin Dermatol. 2010 Mar 4;28(2):212-6. doi: 10.1016/j.clindermatol.2009.12.016.

DOI:10.1016/j.clindermatol.2009.12.016

PMID:20347665

Abstract

There presently exists a wide selection of choices in the treatment of superficial mycoses. The main categories of broad-spectrum agents are the allylamines and imidazoles, which have been tried and proven over more than 2 decades of usage with good safety. Nystatin and griseofulvin have even longer experience of about 5 decades but have niche usage for yeasts and dermatophytes, respectively. Although no new therapeutic groups have appeared, extensive development of vehicles and delivery systems has enhanced therapeutic results and increased patient compliance.

摘要

目前，治疗浅部真菌感染有很多选择。广谱药物的主要类别是烯丙胺和咪唑类，它们经过 20 多年的使用，安全性良好，已得到验证。制霉菌素和灰黄霉素的使用经验甚至更长，约 50 年，但分别针对酵母菌和皮肤癣菌。虽然没有新的治疗类别出现，但载体和给药系统的广泛发展提高了治疗效果，增加了患者的依从性。