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本文引用的文献

1
A PCR-based protocol for the generation of a recombinant West Nile virus.一种基于聚合酶链式反应（PCR）的用于产生重组西尼罗河病毒的方案。
Virus Res. 2009 Sep;144(1-2):35-43. doi: 10.1016/j.virusres.2009.03.021. Epub 2009 Apr 7.
2
West Nile virus envelope protein glycosylation is required for efficient viral transmission by Culex vectors.西尼罗河病毒包膜蛋白糖基化是库蚊媒介有效传播病毒所必需的。
Virology. 2009 Apr 25;387(1):222-8. doi: 10.1016/j.virol.2009.01.038. Epub 2009 Feb 27.
3
[West Nile fever/encephalitis].[西尼罗河热/脑炎]
Uirusu. 2007 Dec;57(2):199-205. doi: 10.2222/jsv.57.199.
4
A single positively selected West Nile viral mutation confers increased virogenesis in American crows.一个经过正向选择的西尼罗河病毒突变会增加美国乌鸦的病毒生成。
Nat Genet. 2007 Sep;39(9):1162-6. doi: 10.1038/ng2097. Epub 2007 Aug 12.
5
Characterization of a small plaque variant of West Nile virus isolated in New York in 2000.2000年在纽约分离出的西尼罗河病毒小斑块变异株的特性分析。
Virology. 2007 Oct 25;367(2):339-47. doi: 10.1016/j.virol.2007.06.008. Epub 2007 Jul 6.
6
Avian virulence and thermostable replication of the North American strain of West Nile virus.西尼罗河病毒北美毒株的禽致病性和耐热复制
J Gen Virol. 2006 Dec;87(Pt 12):3611-3622. doi: 10.1099/vir.0.82299-0.
7
A single amino acid substitution in the central portion of the West Nile virus NS4B protein confers a highly attenuated phenotype in mice.西尼罗河病毒NS4B蛋白中部的单个氨基酸取代在小鼠中赋予高度减毒的表型。
Virology. 2006 Jun 5;349(2):245-53. doi: 10.1016/j.virol.2006.03.007. Epub 2006 Apr 19.
8
West Nile virus detection in the organs of naturally infected blue jays (Cyanocitta cristata).在自然感染西尼罗河病毒的冠蓝鸦（冠蓝鸦属）器官中检测到西尼罗河病毒
J Wildl Dis. 2005 Apr;41(2):354-62. doi: 10.7589/0090-3558-41.2.354.
9
Envelope protein glycosylation status influences mouse neuroinvasion phenotype of genetic lineage 1 West Nile virus strains.包膜蛋白糖基化状态影响基因谱系1西尼罗河病毒株的小鼠神经侵袭表型。
J Virol. 2005 Jul;79(13):8339-47. doi: 10.1128/JVI.79.13.8339-8347.2005.
10
Role of the N-linked glycans of the prM and E envelope proteins in tick-borne encephalitis virus particle secretion.蜱传脑炎病毒颗粒分泌过程中prM和E包膜蛋白的N-连接聚糖的作用
Vaccine. 2005 Apr 27;23(23):3043-52. doi: 10.1016/j.vaccine.2004.11.068.

西尼罗河病毒包膜蛋白的糖基化增加了鸟类体内和体外的病毒繁殖。

Glycosylation of the West Nile Virus envelope protein increases in vivo and in vitro viral multiplication in birds.

机构信息

Laboratory of Public Health, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido, Japan.

出版信息

Am J Trop Med Hyg. 2010 Apr;82(4):696-704. doi: 10.4269/ajtmh.2010.09-0262.

DOI:10.4269/ajtmh.2010.09-0262
PMID:20348522
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2844573/
Abstract

Many West Nile (WN) virus isolates associated with significant outbreaks possess a glycosylation site on the envelope (E) protein. E-protein glycosylated variants of New York (NY) strains of WN virus are more neuroinvasive in mice than the non-glycosylated variants. To determine how E protein glycosylation affects the interactions between WN virus and avian hosts, we inoculated young chicks with NY strains of WN virus containing either glycosylated or non-glycosylated variants of the E protein. The glycosylated variants were more virulent and had higher viremic levels than the non-glycosylated variants. The glycosylation status of the variant did not affect viral multiplication and dissemination in mosquitoes in vivo. Glycosylated variants showed more heat-stable propagation than non-glycosylated variants in mammalian (BHK) and avian (QT6) cells but not in mosquito (C6/36) cells. Thus, E-protein glycosylation may be a requirement for efficient transmission of WN virus from avian hosts to mosquito vectors.

摘要

许多与重大疫情相关的西尼罗河（WN）病毒分离株在包膜（E）蛋白上具有糖基化位点。与非糖基化变体相比，WN 病毒纽约（NY）株的 E 蛋白糖基化变体在小鼠中具有更强的神经侵袭性。为了确定 E 蛋白糖基化如何影响 WN 病毒与禽宿主之间的相互作用，我们用含有 E 蛋白糖基化或非糖基化变体的 NY 株 WN 病毒接种幼鸡。糖基化变体比非糖基化变体更具毒力，且病毒血症水平更高。变体的糖基化状态并不影响病毒在体内蚊子中的复制和传播。与非糖基化变体相比，糖基化变体在哺乳动物（BHK）和禽类（QT6）细胞中的热稳定性繁殖能力更强，但在蚊子（C6/36）细胞中则不然。因此，E 蛋白糖基化可能是 WN 病毒从禽宿主高效传播到蚊子媒介所必需的。