Renz H, Brehler C, Petzoldt S, Prinz H, Rieger C H
Children's Hospital, Marburg, Germany.
Acta Paediatr Scand. 1991 Feb;80(2):149-54. doi: 10.1111/j.1651-2227.1991.tb11825.x.
One hundred and fifty-eight healthy mature newborns were divided into 3 groups according to their risk of allergy: Group A, no risk (n = 62), group B, low risk (n = 30) and Group C, high risk (n = 66). Saliva was collected at birth and after 3 and 6 months. SIgA anti-casein and anti-beta-lactoglobulin were determined by a direct ELISA technique. The highest concentrations of secretory antibodies were measured after birth. After 3 months, breast fed infants had lower salivary SIgA anti-casein concentrations than the group receiving cow's milk (p less than 0.01). The effect of breast-feeding was seen even after a nursing period of only 3 weeks. Infants without risk of allergy fed cow's milk exclusively had higher SIgA anti-casein (p less than 0.03) and anti-beta-lactoglobulin concentrations than low risk infants at the age of 6 months. These data show a modifying effect of breast feeding on salivary SIgA production against cow's milk protein.
158名健康成熟的新生儿根据过敏风险被分为3组：A组，无风险（n = 62）；B组，低风险（n = 30）；C组，高风险（n = 66）。在出生时、3个月和6个月后采集唾液。采用直接ELISA技术测定唾液中抗酪蛋白和抗β-乳球蛋白的分泌型免疫球蛋白A（SIgA）。出生后分泌抗体的浓度最高。3个月后，母乳喂养的婴儿唾液中抗酪蛋白SIgA浓度低于接受牛奶喂养的组（p < 0.01）。即使仅经过3周的母乳喂养期，也能观察到母乳喂养的效果。在6个月时，无过敏风险且完全以牛奶喂养的婴儿抗酪蛋白SIgA（p < 0.03）和抗β-乳球蛋白浓度高于低风险婴儿。这些数据表明母乳喂养对针对牛奶蛋白的唾液SIgA产生有调节作用。
