Department of Anaesthesiology, Dupuytren Teaching Hospital, Limoges, France.
Basic Clin Pharmacol Toxicol. 2010 Aug;107(2):698-9. doi: 10.1111/j.1742-7843.2010.00566.x. Epub 2010 Mar 26.
This report involves a 54-year-old man who died following refractory ventricular fibrillation after ingestion of a plant in a suicide attempt. Repeated direct-current cardioversions were unsuccessful and no single anti-arrhythmic agent was effective for arrhythmia control. The routine blood toxicological screening was negative. Aconitine, the main toxin of Aconitum napellus was identified using a specific liquid chromatography-tandem mass spectrometry (LC-MS/MS) method. The whole blood concentration (24 microg/l) was higher than those reported in other aconitine-related deaths. The patient had found information about the life-threatening nature of such a toxic herb intake on a free medical encyclopedia online.
本报告涉及一名 54 岁男子，他在试图自杀时摄入一种植物后出现难治性心室颤动而死亡。反复进行直流电复律均未成功，且单一抗心律失常药物对心律失常控制均无效。常规血液毒理学筛查为阴性。使用特定的液相色谱-串联质谱（LC-MS/MS）方法鉴定出，乌头碱是乌头属植物的主要毒素。全血浓度（24 微克/升）高于其他与乌头碱相关死亡报告中的浓度。患者在一个免费的在线医学百科全书中找到了有关摄入这种有毒草药会有生命危险的信息。
