Departamento de Bioquímica, Facultad de Medicina, Universidad Nacional Autónoma de México, México, D.F., México.
Lipids Health Dis. 2010 Mar 31;9:35. doi: 10.1186/1476-511X-9-35.
Oxidative damage has been proposed as a possible mechanism involved in lead toxicity, specially affecting the liver and kidney. Previous studies have shown the antioxidant effect of Spirulina maxima in several experimental models of oxidative stress. The current study was carried out to evaluate the antioxidant activity of Spirulina maxima against lead acetate-induced hyperlipidemia and oxidative damage in the liver and kidney of male rats. Control animals were fed on a standard diet and did not receive lead acetate (Control group). Experimental animals were fed on a standard laboratory diet with or without Spirulina maxima 5% in the standard laboratory diet and treated with three doses of lead acetate (25 mg each/weekly, intraperitoneal injection) (lead acetate with Spirulina, and lead acetate without Spirulina groups).
The results showed that Spirulina maxima prevented the lead acetate-induced significant changes on plasma and liver lipid levels and on the antioxidant status of the liver and kidney. On the other hand, Spirulina maxima succeeded to improve the biochemical parameters of the liver and kidney towards the normal values of the Control group.
It was concluded that Spirulina maxima has protective effects on lead acetate-induced damage, and that the effects are associated with the antioxidant effect of Spirulina.
氧化损伤被认为是铅中毒的一种可能机制，特别是对肝脏和肾脏有影响。先前的研究表明，螺旋藻在几种氧化应激实验模型中具有抗氧化作用。本研究旨在评估螺旋藻对醋酸铅诱导的雄性大鼠高血脂和肝肾氧化损伤的抗氧化活性。对照组动物喂食标准饮食，不给予醋酸铅（对照组）。实验组动物喂食标准实验室饮食，或在标准实验室饮食中添加 5%的螺旋藻，并接受三种剂量的醋酸铅（每次 25 毫克/每周，腹腔注射）（含螺旋藻的醋酸铅组和不含螺旋藻的醋酸铅组）。
结果表明，螺旋藻可预防醋酸铅引起的血浆和肝脏脂质水平以及肝脏和肾脏抗氧化状态的显著变化。另一方面，螺旋藻成功地使肝肾功能的生化参数向对照组的正常水平改善。
综上所述，螺旋藻对醋酸铅诱导的损伤具有保护作用，其作用与螺旋藻的抗氧化作用有关。
