Faden H, Glasgow L A, Overall J C
Infect Immun. 1978 Jan;19(1):94-100. doi: 10.1128/iai.19.1.94-100.1978.
A number of viruses have been shown to suppress a variety of host defense mechanisms. To further define the effect of a viral infection on host resistance, a number of parameters were examined during the course of a lethal encephalomyocarditis virus infection of mice. The peripheral lymphocyte count, the induction of interferon in spleen cells by Newcastle disease virus, and the proportion of B cells in the spleen were all decreased or suppressed. In contrast, the responsiveness of spleen lymphocytes to phytohemagglutinin, the delayed-type skin hypersensitivity to dinitrofluorobenzene, and the proportion of T cells in the spleen remained normal. These results indicate that a viral infection may have divergent effects on different parameters of host resistance and emphasize the need to examine several functions before drawing conclusions about the effect of viral infections on host defense mechanisms.
已证实多种病毒可抑制多种宿主防御机制。为进一步明确病毒感染对宿主抵抗力的影响，在小鼠致死性脑心肌炎病毒感染过程中检测了多个参数。外周淋巴细胞计数、新城疫病毒诱导脾细胞产生干扰素的能力以及脾脏中B细胞的比例均降低或受到抑制。相比之下，脾淋巴细胞对植物血凝素的反应性、对二硝基氟苯的迟发型皮肤超敏反应以及脾脏中T细胞的比例保持正常。这些结果表明，病毒感染可能对宿主抵抗力的不同参数产生不同影响，并强调在得出病毒感染对宿主防御机制影响的结论之前，需要检测多种功能。
