病毒感染期间人类的细胞介导免疫。I. 风疹对皮肤超敏反应、植物血凝素反应及T淋巴细胞数量的影响。
Cell-mediated immunity in humans during viral infection. I. Effect of rubella on dermal hypersensitivity, phytohemagglutinin response, and T lymphocyte numbers.
作者信息
Kauffman C A, Phair J P, Linnemann C C, Schiff G M
出版信息
Infect Immun. 1974 Jul;10(1):212-5. doi: 10.1128/iai.10.1.212-215.1974.
Abstract
Phytohemagglutinin-induced lymphocyte deoxyribonucleic acid synthesis, dermal hypersensitivity, and peripheral blood thymus-derived lymphocyte numbers were assessed in nine men with experimentally induced rubella infection. Five of these men and two additional volunteers received treatment with tilorone dihydrochloride, an antiviral drug. Response to phytohemagglutinin was not changed during rubella; T lymphocyte numbers in peripheral blood were not influenced by the viral illness. However, dermal hypersensitivity was markedly impaired in all volunteers during the height of the illness. Tilorone alone, or with rubella, had no effect on any of the parameters studied.
摘要
对9名实验性感染风疹的男性，评估了植物血凝素诱导的淋巴细胞脱氧核糖核酸合成、皮肤超敏反应和外周血胸腺来源淋巴细胞数量。其中5名男性和另外2名志愿者接受了抗病毒药物盐酸替洛隆治疗。在风疹感染期间，对植物血凝素的反应没有改变；外周血中的T淋巴细胞数量不受病毒感染的影响。然而，在疾病高峰期，所有志愿者的皮肤超敏反应均明显受损。单独使用替洛隆或与风疹一起使用，对所研究的任何参数均无影响。
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