Graves 病住院患者的癌症风险：瑞典基于人群的队列研究。
Cancer risk in patients hospitalised for Graves' disease: a population-based cohort study in Sweden.
机构信息
Center for Family and Community Medicine, Karolinska Institute, 141 83 Huddinge, Sweden.
出版信息
Br J Cancer. 2010 Apr 27;102(9):1397-9. doi: 10.1038/sj.bjc.6605624. Epub 2010 Mar 30.
Abstract
BACKGROUND
The possibility of an association of Graves' disease (GD) with subsequent cancers raised by certain studies.
METHODS
Using a database on 18 156 hospitalised GD patients, subsequent cancers were ascertained.
RESULTS
Increased risks of thyroid and parathyroid tumours were limited to the early follow-up period, which is probably a surveillance bias. Cancer sites with observed excess included the mouth and breast, in contrast to decreased risks of colon cancer, melanoma and non-Hodgkin's lymphoma.
CONCLUSION
Increased subsequent cancers in GD patients appeared to be balanced by decreased risks at other sites; chance cannot be excluded.
摘要
背景
一些研究表明 Graves 病（GD）与随后发生的癌症之间存在关联的可能性。
方法
利用一个包含 18156 名住院 GD 患者的数据库，确定了随后发生的癌症病例。
结果
甲状腺和甲状旁腺瘤的风险增加仅限于早期随访期，这可能是一种监测偏差。观察到的肿瘤部位包括口腔和乳房，而结肠癌、黑色素瘤和非霍奇金淋巴瘤的风险则降低。
结论
GD 患者随后发生的癌症风险增加似乎被其他部位风险降低所平衡；不能排除偶然因素的影响。
相似文献
1
Cancer risk in patients hospitalised for Graves' disease: a population-based cohort study in Sweden.Graves 病住院患者的癌症风险：瑞典基于人群的队列研究。
Br J Cancer. 2010 Apr 27;102(9):1397-9. doi: 10.1038/sj.bjc.6605624. Epub 2010 Mar 30.
2
Cancer risk in patients with Graves' disease: a nationwide cohort study.Graves 病患者的癌症风险：一项全国性队列研究。
Thyroid. 2013 Jul;23(7):879-84. doi: 10.1089/thy.2012.0568.
3
Evidence of an association between non-Hodgkin's lymphoma and skin cancer.非霍奇金淋巴瘤与皮肤癌之间存在关联的证据。
BMJ. 1995 Jun 10;310(6993):1491-5. doi: 10.1136/bmj.310.6993.1491.
4
Nonendocrine cancers associated with benign and malignant parathyroid tumors.与良性和恶性甲状旁腺肿瘤相关的非内分泌癌。
J Clin Endocrinol Metab. 2011 Jul;96(7):E1108-14. doi: 10.1210/jc.2011-0099. Epub 2011 Apr 27.
5
Cancer risks among female farmers in Sweden.瑞典女性农民的癌症风险。
Cancer Causes Control. 1994 Sep;5(5):449-57. doi: 10.1007/BF01694759.
6
Second cancer following cutaneous melanoma and cancers of the brain, thyroid, connective tissue, bone, and eye in Denmark, 1943-80.1943 - 1980年丹麦皮肤黑色素瘤以及脑、甲状腺、结缔组织、骨和眼癌之后的第二原发性癌症。
Natl Cancer Inst Monogr. 1985 Dec;68:361-88.
7
Skin cancer and non-Hodgkin's lymphoma as second malignancies. markers of impaired immune function?皮肤癌和非霍奇金淋巴瘤作为第二原发恶性肿瘤。免疫功能受损的标志物？
Eur J Cancer. 2003 Jan;39(2):223-9. doi: 10.1016/s0959-8049(02)00595-6.
8
Relation of benzodiazepine use to the risk of selected cancers: breast, large bowel, malignant melanoma, lung, endometrium, ovary, non-Hodgkin's lymphoma, testis, Hodgkin's disease, thyroid, and liver.
Am J Epidemiol. 1995 Jun 15;141(12):1153-60. doi: 10.1093/oxfordjournals.aje.a117388.
9
Cancer risks in second-generation immigrants to Sweden.瑞典第二代移民的癌症风险。
Int J Cancer. 2002 May 10;99(2):229-37. doi: 10.1002/ijc.10323.
10
[SENTIERI Project: discussion and conclusions].[SENTIERI项目：讨论与结论]
Epidemiol Prev. 2014 Mar-Apr;38(2 Suppl 1):125-33.
引用本文的文献
1
Process to radioactive iodine treatment for Graves' hyperthyroidism: condemned or absolved?格雷夫斯病甲亢的放射性碘治疗流程：应受谴责还是可免责？
J Endocrinol Invest. 2025 Aug 6. doi: 10.1007/s40618-025-02653-x.
2
Variable hyperthyroidism outcomes related to different treatment regimens: an analysis of UK Biobank data.与不同治疗方案相关的可变甲状腺功能亢进症结局：基于英国生物银行数据的分析
Eur Thyroid J. 2025 Apr 14;14(2). doi: 10.1530/ETJ-24-0393. Print 2025 Apr 1.
3
Survival in Thyroid Cancer in Sweden From 1999 To 2018.1999年至2018年瑞典甲状腺癌患者的生存率
Clin Epidemiol. 2024 Oct 2;16:659-671. doi: 10.2147/CLEP.S467874. eCollection 2024.
4
Association between thyroid disorders and extra-thyroidal cancers, a review.甲状腺疾病与甲状腺外癌症的关联：综述
Clin Transl Oncol. 2024 Sep;26(9):2075-2083. doi: 10.1007/s12094-024-03434-3. Epub 2024 Mar 15.
5
Genetically predicted thyroid function and risk of colorectal cancer: a bidirectional Mendelian randomization study.基因预测的甲状腺功能与结直肠癌风险：一项双向孟德尔随机化研究
J Cancer Res Clin Oncol. 2023 Nov;149(15):14015-14024. doi: 10.1007/s00432-023-05233-9. Epub 2023 Aug 6.
6
Radiation-Related Thyroid Cancer.放射性甲状腺癌。
Endocr Rev. 2024 Jan 4;45(1):1-29. doi: 10.1210/endrev/bnad022.
7
Cancer and Mortality Risks of Graves' Disease in South Korea Based on National Data from 2010 to 2019.基于2010年至2019年韩国全国数据的格雷夫斯病的癌症和死亡风险
Clin Epidemiol. 2023 May 2;15:535-546. doi: 10.2147/CLEP.S406361. eCollection 2023.
8
Insights on the Association between Thyroid Diseases and Colorectal Cancer.甲状腺疾病与结直肠癌关联的见解
J Clin Med. 2023 Mar 13;12(6):2234. doi: 10.3390/jcm12062234.
9
Outcomes of Surgical Treatment for Graves' Disease: A Single-Center Experience of 216 Cases.格雷夫斯病的外科治疗结果：单中心216例经验
J Clin Med. 2023 Feb 7;12(4):1308. doi: 10.3390/jcm12041308.
10
A Comparative Follow-Up Study of Patients with Papillary Thyroid Carcinoma Associated or Not with Graves' Disease.甲状腺乳头状癌合并或不合并格雷夫斯病患者的比较随访研究
Diagnostics (Basel). 2022 Nov 15;12(11):2801. doi: 10.3390/diagnostics12112801.
本文引用的文献
1
Cancer risk in hospitalized sarcoidosis patients: a follow-up study in Sweden.住院结节病患者的癌症风险：瑞典的一项随访研究。
Ann Oncol. 2009 Jun;20(6):1121-6. doi: 10.1093/annonc/mdn767. Epub 2009 Feb 11.
2
Cancer and immune response: old and new evidence for future challenges.癌症与免疫反应：未来挑战的新老证据
Oncologist. 2008 Dec;13(12):1246-54. doi: 10.1634/theoncologist.2008-0166. Epub 2008 Dec 4.
3
Postoperative mortality in parathyroid surgery in Sweden during five decades: improved outcome despite older patients.瑞典五十年间甲状旁腺手术的术后死亡率：尽管患者年龄增大，但结局仍有所改善。
Eur J Endocrinol. 2009 Feb;160(2):295-9. doi: 10.1530/EJE-08-0523. Epub 2008 Nov 28.
4
Immigration and the incidence of Graves' thyrotoxicosis, thyrotoxic multinodular goiter and solitary toxic adenoma.移民与格雷夫斯病甲状腺毒症、毒性多结节性甲状腺肿及孤立性毒性腺瘤的发病率
Eur J Endocrinol. 2009 Feb;160(2):201-6. doi: 10.1530/EJE-08-0548. Epub 2008 Nov 12.
5
Mortality from thyroid cancer in patients with hyperthyroidism: the Theagenion Cancer Hospital experience.甲状腺功能亢进症患者的甲状腺癌死亡率：泰亚吉尼翁癌症医院的经验
Eur J Endocrinol. 2008 Dec;159(6):799-803. doi: 10.1530/EJE-08-0468. Epub 2008 Sep 26.
6
Cancer risks in ulcerative colitis patients.溃疡性结肠炎患者的癌症风险。
Int J Cancer. 2008 Sep 15;123(6):1417-21. doi: 10.1002/ijc.23666.
7
Clinical practice. Graves' disease.临床实践。格雷夫斯病。
N Engl J Med. 2008 Jun 12;358(24):2594-605. doi: 10.1056/NEJMcp0801880.
8
Incidence of hyperthyroidism in Stockholm, Sweden, 2003-2005.2003年至2005年瑞典斯德哥尔摩甲状腺功能亢进症的发病率。
Eur J Endocrinol. 2008 Jun;158(6):823-7. doi: 10.1530/EJE-07-0877.
9
Surgical treatment of Graves' disease: evidence-based approach.格雷夫斯病的外科治疗：循证医学方法
World J Surg. 2008 Jul;32(7):1269-77. doi: 10.1007/s00268-008-9497-9.
10
The immune system--is it relevant to cancer development, progression and treatment?免疫系统——它与癌症的发生、发展及治疗有关吗？
Clin Oncol (R Coll Radiol). 2008 Mar;20(2):101-12. doi: 10.1016/j.clon.2007.10.011. Epub 2007 Nov 26.
Zotero 插件