Graves 病住院患者的癌症风险：瑞典基于人群的队列研究。
Cancer risk in patients hospitalised for Graves' disease: a population-based cohort study in Sweden.
机构信息
Center for Family and Community Medicine, Karolinska Institute, 141 83 Huddinge, Sweden.
出版信息
Br J Cancer. 2010 Apr 27;102(9):1397-9. doi: 10.1038/sj.bjc.6605624. Epub 2010 Mar 30.
Abstract
BACKGROUND
The possibility of an association of Graves' disease (GD) with subsequent cancers raised by certain studies.
METHODS
Using a database on 18 156 hospitalised GD patients, subsequent cancers were ascertained.
RESULTS
Increased risks of thyroid and parathyroid tumours were limited to the early follow-up period, which is probably a surveillance bias. Cancer sites with observed excess included the mouth and breast, in contrast to decreased risks of colon cancer, melanoma and non-Hodgkin's lymphoma.
CONCLUSION
Increased subsequent cancers in GD patients appeared to be balanced by decreased risks at other sites; chance cannot be excluded.
摘要
背景
一些研究表明 Graves 病（GD）与随后发生的癌症之间存在关联的可能性。
方法
利用一个包含 18156 名住院 GD 患者的数据库，确定了随后发生的癌症病例。
结果
甲状腺和甲状旁腺瘤的风险增加仅限于早期随访期，这可能是一种监测偏差。观察到的肿瘤部位包括口腔和乳房，而结肠癌、黑色素瘤和非霍奇金淋巴瘤的风险则降低。
结论
GD 患者随后发生的癌症风险增加似乎被其他部位风险降低所平衡；不能排除偶然因素的影响。
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