Gagliardi Federica, Baldini Enke, Lori Eleonora, Cardarelli Silvia, Pironi Daniele, Lauro Augusto, Tripodi Domenico, Palumbo Piergaspare, D'Armiento Eleonora, Cavallaro Giuseppe, Polistena Andrea, D'Orazi Valerio, Sibio Simone, Fallahi Poupak, Antonelli Alessandro, D'Andrea Vito, Ulisse Salvatore, Sorrenti Salvatore
Department of Surgery, "Sapienza" University of Rome, 00161 Rome, Italy.
Department of Internal Medicine and Medical Specialties, "Sapienza" University of Rome, 00161 Rome, Italy.
J Clin Med. 2023 Mar 13;12(6):2234. doi: 10.3390/jcm12062234.
Benign and malignant thyroid diseases (TDs) have been associated with the occurrence of extrathyroidal malignancies (EMs), including colorectal cancers (CRCs). Such associations have generated a major interest, as their characterization may provide useful clues regarding diseases' etiology and/or progression, with the possible identification of shared congenital and environmental elements. On the other hand, elucidation of the underlying molecular mechanism(s) could lead to an improved and tailored clinical management of these patients and stimulate an increased surveillance of TD patients at higher threat of developing EMs. Here, we will examine the epidemiological, clinical, and molecular findings connecting TD and CRC, with the aim to identify possible molecular mechanism(s) responsible for such diseases' relationship.
良性和恶性甲状腺疾病（TDs）与甲状腺外恶性肿瘤（EMs）的发生有关，包括结直肠癌（CRCs）。这种关联引起了人们的极大兴趣，因为对它们的特征描述可能为疾病的病因和/或进展提供有用线索，有可能识别出共同的先天性和环境因素。另一方面，阐明潜在的分子机制可能会改善这些患者的临床管理并实现个性化治疗，并促使对发生EMs风险较高的TD患者加强监测。在此，我们将研究连接TD和CRC的流行病学、临床和分子学发现，旨在确定造成这些疾病之间关系的可能分子机制。
