Abraham-Nordling Mirna, Törring Ove, Lantz Mikael, Hallengren Bengt, Ohrling Hans, Lundell Göran, Calissendorff Jan, Jörneskog Gun, Wallin Göran
Division of Surgery, Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska University Hospital, SE-17176 Stockholm, Sweden.
Eur J Endocrinol. 2008 Jun;158(6):823-7. doi: 10.1530/EJE-07-0877.
To investigate the incidence of hyperthyroidism in Stockholm County, in those patients who were diagnosed with hyperthyroidism for the first time during the years 2003-2005.
All new cases of hyperthyroidism > or = 18 years of age were prospectively registered to calculate the total incidence of hyperthyroidism, as well as the incidence of the subgroups: Graves' disease (GD), toxic multinodular goitre and solitary toxic adenoma (STA). Eight specialized units/hospitals in Stockholm County participated in the registration. The participating physicians were all specialists in medical endocrinology, oncology, nuclear medicine or surgery.
During a 3-year period, 1431 new patients of hyperthyroidism were diagnosed in a well-defined adult population (> 18 years of age) of in average 1,457,036 inhabitants. This corresponds to a mean annual incidence of hyperthyroidism of 32.7/100,000. The incidence of GD was 24.5/100,000 per year, toxic nodular goitre was 3.3/100,000 per year and STA was 4.9/100,000 per year.
The total incidence of hyperthyroidism in Stockholm County was found to be 32.7/100,000 per year, of which 75% had GD. There were a higher percentage of smokers among the patients with hyperthyroidism compared with the overall population in Stockholm, but no difference in the frequency of smoking between patients with GD and toxic nodular goitre.
调查2003年至2005年期间首次被诊断为甲状腺功能亢进症的斯德哥尔摩县患者中甲状腺功能亢进症的发病率。
前瞻性登记所有年龄≥18岁的甲状腺功能亢进症新病例，以计算甲状腺功能亢进症的总发病率以及亚组的发病率：格雷夫斯病（GD）、毒性多结节性甲状腺肿和孤立性毒性腺瘤（STA）。斯德哥尔摩县的8个专科单位/医院参与了登记。参与的医生均为医学内分泌学、肿瘤学、核医学或外科方面的专家。
在3年期间，在平均有1457036名居民的明确成年人群（年龄>18岁）中诊断出1431例甲状腺功能亢进症新患者。这相当于甲状腺功能亢进症的年平均发病率为32.7/10万。GD的发病率为每年24.5/10万，毒性结节性甲状腺肿为每年3.3/10万，STA为每年4.9/10万。
发现斯德哥尔摩县甲状腺功能亢进症的总发病率为每年32.7/10万，其中75%患有GD。与斯德哥尔摩的总体人群相比，甲状腺功能亢进症患者中的吸烟者比例更高，但GD患者和毒性结节性甲状腺肿患者之间的吸烟频率没有差异。
