Insig2基因rs7566605多态性的常见遗传变异与印度北部的严重肥胖有关。
Common Genetic Variant of insig2 Gene rs7566605 Polymorphism Is Associated with Severe Obesity in North India.
作者信息
Prakash Jai, Mittal Balraj, Apurva Srivastava, Shally Awasthi, Pranjal Srivastava, Neena Srivastava
机构信息
Department of Physiology, King George’s Medical University, Lucknow, Uttar Pradesh, India.
2Department of Pediatrics, King George’s Medical University, Lucknow, Uttar Pradesh, India.
出版信息
Iran Biomed J. 2017 Jul;21(4):261-9. doi: 10.18869/acadpub.ibj.21.4.261. Epub 2017 May 21.
BACKGROUND
Obesity is a very common disorder resulting from an imbalance between food intake and energy expenditure, and it has a substantial impact on the development of chronic diseases. The aim of this study was to examine the association of INSIG2 (rs7566605) gene polymorphism with obesity and obesity associated phenotypes in North Indian subjects.
METHODS
The variants were investigated for association in 642 obese and non-obese individuals. The genotyping of INSIG2 (rs7566605) single nucleotide polymorphism was analyzed by the TaqMan allelic discrimination protocol.
RESULTS
A significant association was observed for INSIG2 (rs7566605) single nucleotide polymorphism with obesity and obesity-related phenotypes. Furthermore, a significant relationship was found between the rs7566605 and insulin, homeostasis model of assessment-insulin resistance, the percentage of body fat, fat mass, leptin, and adiponectin.
CONCLUSION
The present study observed significant association between INSIG2 (rs7566605) single nucleotide polymorphism and obesity, as well as obesity-associated phenotypes in North Indian population.
背景
肥胖是一种因食物摄入与能量消耗失衡而导致的常见病症，对慢性病的发展有重大影响。本研究旨在探讨印度北部人群中INSIG2（rs7566605）基因多态性与肥胖及肥胖相关表型之间的关联。
方法
对642名肥胖和非肥胖个体的基因变体进行关联研究。采用TaqMan等位基因鉴别法分析INSIG2（rs7566605）单核苷酸多态性的基因分型。
结果
观察到INSIG2（rs7566605）单核苷酸多态性与肥胖及肥胖相关表型之间存在显著关联。此外，还发现rs7566605与胰岛素、稳态模型评估-胰岛素抵抗、体脂百分比、脂肪量、瘦素和脂联素之间存在显著关系。
结论
本研究观察到INSIG2（rs7566605）单核苷酸多态性与印度北部人群的肥胖以及肥胖相关表型之间存在显著关联。
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