Center for Preventive Doping Research-Institute of Biochemistry, German Sport University Cologne, 50933 Cologne, Germany.
Drug Test Anal. 2009 Jan;1(1):4-13. doi: 10.1002/dta.9.
The list of prohibited substances and methods of doping issued by the World Anti-Doping Agency is updated and modified annually based on most recent developments and scientific data. Compounds and methods are maintained, added, or removed from the list, or they are placed in so-called monitoring programmes that have been established to obtain reliable data on the prevalence of particular substances and methods in- and/or out-of-competition. Consequently, doping control laboratories continuously update, modify and optimize existing screening and confirmation assays to ensure utmost comprehensiveness in detecting the prohibited and monitored substances as well as chemically and pharmacologically related analogs. The annual banned-substance review for human sports drug testing critically summarizes recent innovations in analytical approaches supporting the detection of established and newly outlawed substances and methods of doping. Literature from January 2007 through September 2008 as indexed in Medline and Web of Science was screened and articles on detection methods for substances and methods of doping in humans were compiled according to the 2008 Prohibited List of the World Anti-Doping Agency. Few new approaches were presented for individual doping agents and the majority of reports demonstrated new options for increasing the comprehensiveness of existing doping control assays. In addition, new techniques in separation and/or ionization of analytes complementary to commonly used procedures were described, which, so far, did not meet all requirements of sports drug testing.
世界反兴奋剂机构（WADA）发布的禁用物质和方法清单每年都会根据最新的发展和科学数据进行更新和修改。清单中的化合物和方法会被保留、添加或删除，或者被列入所谓的监测计划，以获取特定物质和方法在比赛内外流行的可靠数据。因此，兴奋剂检测实验室不断更新、修改和优化现有的筛选和确认检测方法，以确保在检测禁用物质和受监测物质以及化学和药理学相关类似物方面具有最大的全面性。人类运动药物检测的年度禁用物质审查批判性地总结了支持检测已确立和新禁用物质和方法的分析方法的最新创新。对 2007 年 1 月至 2008 年 9 月在 Medline 和 Web of Science 索引的文献进行了筛选，并根据世界反兴奋剂机构 2008 年的禁用清单汇编了关于人类物质和方法检测的文章。少数新方法被用于个别兴奋剂，大多数报告则展示了增加现有兴奋剂控制检测方法全面性的新选择。此外，还描述了与常用程序互补的分析物分离和/或离子化的新技术，这些技术迄今为止还没有满足运动药物检测的所有要求。
