Thevis Mario, Kuuranne Tiia, Walpurgis Katja, Geyer Hans, Schänzer Wilhelm
Center for Preventive Doping Research, Institute of Biochemistry, German Sport University Cologne, Am Sportpark Müngersdorf 6, 50933, Cologne, Germany.
European Monitoring Center for Emerging Doping Agents, Cologne/Bonn, Germany.
Drug Test Anal. 2016 Jan;8(1):7-29. doi: 10.1002/dta.1928. Epub 2016 Jan 15.
The aim of improving anti-doping efforts is predicated on several different pillars, including, amongst others, optimized analytical methods. These commonly result from exploiting most recent developments in analytical instrumentation as well as research data on elite athletes' physiology in general, and pharmacology, metabolism, elimination, and downstream effects of prohibited substances and methods of doping, in particular. The need for frequent and adequate adaptations of sports drug testing procedures has been incessant, largely due to the uninterrupted emergence of new chemical entities but also due to the apparent use of established or even obsolete drugs for reasons other than therapeutic means, such as assumed beneficial effects on endurance, strength, and regeneration capacities. Continuing the series of annual banned-substance reviews, literature concerning human sports drug testing published between October 2014 and September 2015 is summarized and reviewed in reference to the content of the 2015 Prohibited List as issued by the World Anti-Doping Agency (WADA), with particular emphasis on analytical approaches and their contribution to enhanced doping controls.
提高反兴奋剂工作成效的目标基于几个不同的支柱，其中包括优化分析方法等。这些通常源于利用分析仪器的最新进展以及关于精英运动员一般生理学的研究数据，特别是关于禁用物质和兴奋剂方法的药理学、代谢、消除及下游效应的研究数据。由于新化学实体不断涌现，而且由于出于治疗以外的原因（如假定对耐力、力量和恢复能力有有益影响）明显使用已有的甚至过时的药物，因此不断需要对运动药物检测程序进行频繁且适当的调整。继续年度禁用物质审查系列，总结并参考世界反兴奋剂机构（WADA）发布的2015年《禁用清单》的内容，对2014年10月至2015年9月期间发表的有关人类运动药物检测的文献进行审查，特别强调分析方法及其对加强兴奋剂控制的贡献。
