Center for Preventive Doping Research - Institute of Biochemistry, German Sport University Cologne, Cologne, Germany.
European Monitoring Center for Emerging Doping Agents, Cologne, Germany.
Drug Test Anal. 2021 Jan;13(1):8-35. doi: 10.1002/dta.2969. Epub 2020 Dec 2.
Analytical chemistry-based research in sports drug testing has been a dynamic endeavor for several decades, with technology-driven innovations continuously contributing to significant improvements in various regards including analytical sensitivity, comprehensiveness of target analytes, differentiation of natural/endogenous substances from structurally identical but synthetically derived compounds, assessment of alternative matrices for doping control purposes, and so forth. The resulting breadth of tools being investigated and developed by anti-doping researchers has allowed to substantially improve anti-doping programs and data interpretation in general. Additionally, these outcomes have been an extremely valuable pledge for routine doping controls during the unprecedented global health crisis that severely affected established sports drug testing strategies. In this edition of the annual banned-substance review, literature on recent developments in anti-doping published between October 2019 and September 2020 is summarized and discussed, particularly focusing on human doping controls and potential applications of new testing strategies to substances and methods of doping specified the World Anti-Doping Agency's 2020 Prohibited List.
基于分析化学的运动药物检测研究已经活跃了几十年，技术驱动的创新不断为各个方面带来显著的改进，包括分析灵敏度、目标分析物的全面性、天然/内源性物质与结构相同但源自合成的化合物的区分、替代基质用于兴奋剂控制的评估等。反兴奋剂研究人员正在研究和开发的这些工具的广泛应用使得兴奋剂检测计划和数据解释得到了极大的改进。此外，在严重影响既定运动药物检测策略的前所未有的全球健康危机期间，这些结果对于常规兴奋剂检测是极其有价值的保证。在本年度的禁用物质审查中，总结和讨论了 2019 年 10 月至 2020 年 9 月期间发表的关于反兴奋剂最新进展的文献，特别关注人类兴奋剂控制以及新检测策略在世界反兴奋剂机构 2020 年禁用清单中规定的物质和方法中的潜在应用。
