Thevis Mario, Kuuranne Tiia, Geyer Hans, Schänzer Wilhelm
Center for Preventive Doping Research - Institute of Biochemistry, German Sport University Cologne, Am Sportpark Müngersdorf 6, 50933, Cologne, Germany; European Monitoring Center for Emerging Doping Agents, Cologne, Germany.
Drug Test Anal. 2015 Jan;7(1):1-20. doi: 10.1002/dta.1769. Epub 2014 Dec 26.
Within the mosaic display of international anti-doping efforts, analytical strategies based on up-to-date instrumentation as well as most recent information about physiology, pharmacology, metabolism, etc., of prohibited substances and methods of doping are indispensable. The continuous emergence of new chemical entities and the identification of arguably beneficial effects of established or even obsolete drugs on endurance, strength, and regeneration, necessitate frequent and adequate adaptations of sports drug testing procedures. These largely rely on exploiting new technologies, extending the substance coverage of existing test protocols, and generating new insights into metabolism, distribution, and elimination of compounds prohibited by the World Anti-Doping Agency (WADA). In reference of the content of the 2014 Prohibited List, literature concerning human sports drug testing that was published between October 2013 and September 2014 is summarized and reviewed in this annual banned-substance review, with particular emphasis on analytical approaches and their contribution to enhanced doping controls.
在国际反兴奋剂工作的整体布局中，基于最新仪器设备以及关于禁用物质和兴奋剂方法的生理学、药理学、代谢等方面最新信息的分析策略不可或缺。新化学实体的不断涌现，以及已有的甚至过时的药物对耐力、力量和恢复方面可能存在的有益作用的发现，使得体育药物检测程序需要频繁且充分地进行调整。这些调整很大程度上依赖于利用新技术、扩大现有检测方案的物质覆盖范围，以及对世界反兴奋剂机构（WADA）禁用化合物的代谢、分布和消除产生新的认识。参照2014年《禁用清单》的内容，本年度禁用物质综述总结并回顾了2013年10月至2014年9月期间发表的有关人体体育药物检测的文献，特别强调了分析方法及其对加强兴奋剂管控的贡献。
