Holberg C J, Wright A L, Martinez F D, Ray C G, Taussig L M, Lebowitz M D
Division of Respiratory Sciences, University of Arizona Health Sciences Center, Tucson.
Am J Epidemiol. 1991 Jun 1;133(11):1135-51. doi: 10.1093/oxfordjournals.aje.a115826.
The relation of breast feeding and other factors to the incidence of respiratory syncytial virus-associated lower respiratory tract illness (RSV-LRI) in the first year of life is examined. The study population is 1,179 healthy infants enrolled at birth between May 1980 and January 1984 into the Tucson Children's Respiratory Study, Tucson, Arizona. Each subject's data were assessed at each month of age during the first year of life, during those months when respiratory syncytial virus was isolated. A number of significant relations were observed, particularly between 1 and 3 months of age. At this age, the risk of having a RSV-LRI increased in association with less than 1-month or no breast feeding, with being male, and with increasing numbers of others sharing the child's bedroom. In multivariate analysis, only sex and the number of others sharing the room remained as significant direct effects. However, a significant interaction demonstrated that breast feeding has a protective role in relation to RSV-LRIs for those infants of mothers with a lower education level. The risk of having a RSV-LRI increases with combinations of risk factors. Being in day care was a significant risk factor in the 7- to 9-month age range. The RSV-LRI rate also varies by birth month. A separate case-control study assessed relations of RSV-LRIs with cord serum RSV antibody. Those with lower cord serum RSV antibody, who also have minimal breast feeding, were found to be especially at risk for RSV-LRIs in the first 5 months of life.
研究了母乳喂养及其他因素与1岁以内呼吸道合胞病毒相关性下呼吸道疾病（RSV-LRI）发病率之间的关系。研究对象为1980年5月至1984年1月期间在亚利桑那州图森市参加图森儿童呼吸研究的1179名健康婴儿。在生命的第一年，在分离出呼吸道合胞病毒的每个月，对每个受试者的数据进行评估。观察到了一些显著的关系，特别是在1至3个月大时。在这个年龄段，RSV-LRI的患病风险会因以下因素而增加：母乳喂养不足1个月或未进行母乳喂养、男性、与孩子共用卧室的其他人数量增加。在多变量分析中，只有性别和与孩子共用卧室的其他人数量仍然是显著的直接影响因素。然而，一项显著的交互作用表明，母乳喂养对母亲教育水平较低的婴儿的RSV-LRI具有保护作用。RSV-LRI的患病风险会因多种风险因素的组合而增加。在7至9个月大的年龄段，参加日托是一个显著的风险因素。RSV-LRI发病率也因出生月份而异。另一项病例对照研究评估了RSV-LRI与脐带血清RSV抗体之间的关系。发现脐带血清RSV抗体水平较低且母乳喂养极少的婴儿在生命的前5个月尤其易患RSV-LRI。
