Catalano P M, Merritt A O, Mead P B
Department of Obstetrics and Gynecology, University of Vermont College of Medicine, Burlington.
Am J Obstet Gynecol. 1991 May;164(5 Pt 1):1303-6. doi: 10.1016/0002-9378(91)90704-u.
A total of 143 women with known risk factors for genital herpes simplex virus had cultures performed at the time of delivery. A total of 123 were without symptoms, of which three (2.4%) had positive herpes simplex virus cultures at the time of delivery. Fifteen women had lesions clinically consistent with genital herpes simplex virus at the time of delivery and five (33.3%) were culture positive. Five women had only prodromal symptoms of genital herpes simplex virus, but two of these (40%) had positive herpes simplex virus cultures from the site of previous lesions. Of the 10 women with positive herpes simplex virus cultures in this group of 143, no infant was delivered with evidence of neonatal herpes simplex virus infection, including two who had vaginal deliveries. The results of this study support the recommendations that in women without symptoms but with known risk factors for genital herpes simplex virus, a trial of vaginal delivery be allowed and that in women with either a lesion clinically consistent with genital herpes simplex virus or prodromal symptoms of genital herpes simplex virus a cesarean section be the mode of delivery.
共有143名已知有单纯疱疹病毒感染风险因素的女性在分娩时进行了病毒培养。其中123名无症状，其中3名（2.4%）在分娩时单纯疱疹病毒培养呈阳性。15名女性在分娩时有与单纯疱疹病毒感染相符的临床病变，其中5名（33.3%）培养呈阳性。5名女性仅有单纯疱疹病毒前驱症状，但其中2名（40%）从前病变部位的单纯疱疹病毒培养呈阳性。在这143名女性中，有10名单纯疱疹病毒培养呈阳性，没有一名婴儿出生时有新生儿单纯疱疹病毒感染的迹象，包括2名经阴道分娩的婴儿。本研究结果支持以下建议：对于无症状但有已知单纯疱疹病毒感染风险因素的女性，允许试行阴道分娩；对于有与单纯疱疹病毒感染相符的临床病变或单纯疱疹病毒前驱症状的女性，剖宫产应为分娩方式。
