转化生长因子-β1 多态性与原发性高血压患者心房颤动的关系。
Association between transforming growth factor beta1 polymorphisms and atrial fibrillation in essential hypertensive subjects.
机构信息
Department of Interventional Radiology, The Second Hospital of Shandong University, Shangdong, PR China.
出版信息
J Biomed Sci. 2010 Mar 31;17(1):23. doi: 10.1186/1423-0127-17-23.
BACKGROUND
The association of TGF beta1 polymorphisms and atrial fibrillation (AF) in essential hypertensive (EH) subjects remains unknown. Methods EH subjects with AF (EH+AF+) and sinus rhythm (EH+AF-) were enrolled. The polymorphisms of +869 T --> C at codon 10 and + 915 G --> C at codon 25, were genotyped. The clinical characteristics including serum TGF beta1 levels were detected.
RESULTS
The GG genotypes of TGF beta1 +915 G --> C at codon 25 were more prevalent in subjects from EH+AF+ group than those from EH+AF- group (P = 0.009). The subjects with GG genotype from EH+AF+ group had the highest mean serum TGF beta1 level, which was significantly higher than that of GG genotype subjects from EH+AF- group (3.18 +/- 0.24 ng/dl vs.2.29 +/- 0.14 ng/dl, P < 0.05). Multiple analyses revealed that the TGF beta1 GG genotype of +915 G --> C at codon 25 presented a 3.09 times higher risk in developing AF in the multivariate model after adjusting for age and gender.
CONCLUSION
The polymorphisms of TGF beta1 +915 G --> C at codon 25 were associated with occurrence of AF and serum TGF beta1 level in EH subjects.
背景
转化生长因子β 1 （TGFβ1）多态性与原发性高血压（EH）患者心房颤动（AF）的关系尚不清楚。
方法
选择 AF 伴 EH（EH+AF+）和窦性心律伴 EH（EH+AF-）患者，检测 TGFβ1+869T>C 密码子 10 和+915G>C 密码子 25 多态性，分析 TGFβ1 血清水平与 AF 的关系。
结果
EH+AF+组 TGFβ1+915G>C 密码子 25 的 GG 基因型比 EH+AF-组更常见（P=0.009）。EH+AF+组 GG 基因型患者的 TGFβ1 血清水平最高，明显高于 EH+AF-组（3.18±0.24ng/dl 比 2.29±0.14ng/dl，P<0.05）。多变量分析显示，在调整年龄和性别后，TGFβ1+915G>C 密码子 25 的 GG 基因型在多变量模型中使 AF 发生的风险增加 3.09 倍。
结论
TGFβ1+915G>C 密码子 25 多态性与 EH 患者 AF 的发生和 TGFβ1 血清水平有关。
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