Department of Chemistry, University of Rochester, Rochester, NY 14627, USA.
Angew Chem Int Ed Engl. 2010 Apr 26;49(19):3363-6. doi: 10.1002/anie.201000100.
[Image: see text] Pushing the Nazarov Envelope A new electrophilic complex IrBr(CO)(diethylisopropylidene malonate)(()-(+)-BINAP) () exhibits unusual activity in the catalysis of polarized Nazarov cyclization. Aryl vinyl ketones that show poor reactivity with well-known catalysts such as Ir(CH)(CO)(1,2-diiodobenzene)(dppe) (), Sc(OTf) + LiClO and Cu(ClO), can be cyclized with + AgSbF (1:1) under mild conditions with concurrent AgBr precipitation.
推动 Nazarov 反应极限：一种新型亲电配合物IrBr(CO)(二乙基异丙叉丙二酸酯)(()-(+)-BINAP)()在极化 Nazarov 环化反应的催化中表现出异常的活性。芳基乙烯基酮与众所周知的催化剂（如Ir(CH)(CO)(1,2-二碘苯)(dppe)()、Sc(OTf) + LiClO 和 Cu(ClO)）反应活性差，但在温和条件下，用 + AgSbF（1:1）与 AgBr 沉淀同时进行，可以与IrBr(CO)(二乙基异丙叉丙二酸酯)(()-(+)-BINAP)()发生环化反应。
